ID   BROX_DANRE              Reviewed;         411 AA.
AC   A3KQV2; Q5U3R7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=BRO1 domain-containing protein BROX;
DE   AltName: Full=BRO1 domain- and CAAX motif-containing protein;
DE   Flags: Precursor;
GN   Name=brox; ORFNames=si:ch211-14a11.3, zgc:101706;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BROX family. {ECO:0000305}.
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DR   EMBL; BX936461; CAM56323.1; -; Genomic_DNA.
DR   EMBL; BC085420; AAH85420.1; -; mRNA.
DR   RefSeq; NP_001007428.2; NM_001007427.2.
DR   AlphaFoldDB; A3KQV2; -.
DR   SMR; A3KQV2; -.
DR   STRING; 7955.ENSDARP00000115398; -.
DR   PaxDb; A3KQV2; -.
DR   PeptideAtlas; A3KQV2; -.
DR   Ensembl; ENSDART00000004092; ENSDARP00000017102; ENSDARG00000013659.
DR   Ensembl; ENSDART00000147044; ENSDARP00000115398; ENSDARG00000013659.
DR   GeneID; 492786; -.
DR   KEGG; dre:492786; -.
DR   CTD; 148362; -.
DR   ZFIN; ZDB-GENE-041114-137; brox.
DR   eggNOG; ENOG502QQBR; Eukaryota.
DR   GeneTree; ENSGT00390000006681; -.
DR   HOGENOM; CLU_056561_0_0_1; -.
DR   InParanoid; A3KQV2; -.
DR   OMA; HTCLRRA; -.
DR   OrthoDB; 614228at2759; -.
DR   PhylomeDB; A3KQV2; -.
DR   TreeFam; TF314743; -.
DR   PRO; PR:A3KQV2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 20.
DR   Bgee; ENSDARG00000013659; Expressed in brain and 20 other tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR038898; BROX.
DR   PANTHER; PTHR23032; PTHR23032; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..408
FT                   /note="BRO1 domain-containing protein BROX"
FT                   /id="PRO_0000304616"
FT   PROPEP          409..411
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000396740"
FT   DOMAIN          84..403
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          379..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         408
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           408
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        129
FT                   /note="L -> S (in Ref. 2; AAH85420)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="E -> G (in Ref. 2; AAH85420)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   411 AA;  46125 MW;  7339C553974ED5F2 CRC64;
     MTHWFHRNPL KATAPVSFNL YGVASSPAAN KICNDLRTAR ARLLDMFTDA TCSPDTLKKS
     SDEYFALLQG FILPLDGTTQ ENKLRFIQNF KWTDTLQGNI ASAQQDAVFE LVSMAFNVAL
     WYTKFASRLA GKENITEEEA KDVHKSLKIA AGIFKTLKET HIPRLITPAE KGRDLEPRVI
     DTYIVQSQAE AQEVTIARAI ELKHNASLIA ALAFETANFY QKADHTLNTL DPECSSKWKK
     YLQLKQHFYM AYAHCYHGQT LLAGDKCGEA IRSLQEAEKC YSRAEVLCKE YRQMKGPGST
     AKPSEQLFFK KLGAVIKNTL EKCQRENGFI YFHKVPAEAP ALELKASYGL AEPTAFELPP
     LSAQCTPEVY ATFDLTRGHK DDKAKAKPEE EIKPVKEPDL KPQKDTGCVV C