ID   BROX_PONAB              Reviewed;         411 AA.
AC   Q5RDD7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=BRO1 domain-containing protein BROX;
DE   AltName: Full=BRO1 domain- and CAAX motif-containing protein;
DE   Flags: Precursor;
GN   Name=BROX;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with CHMP4B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BROX family. {ECO:0000305}.
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DR   EMBL; CR857976; CAH90220.1; -; mRNA.
DR   RefSeq; NP_001125088.1; NM_001131616.1.
DR   AlphaFoldDB; Q5RDD7; -.
DR   SMR; Q5RDD7; -.
DR   STRING; 9601.ENSPPYP00000000197; -.
DR   Ensembl; ENSPPYT00000000212; ENSPPYP00000000197; ENSPPYG00000000195.
DR   GeneID; 100171970; -.
DR   KEGG; pon:100171970; -.
DR   CTD; 148362; -.
DR   eggNOG; ENOG502QQBR; Eukaryota.
DR   GeneTree; ENSGT00390000006681; -.
DR   HOGENOM; CLU_056561_0_0_1; -.
DR   InParanoid; Q5RDD7; -.
DR   OrthoDB; 614228at2759; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR038898; BROX.
DR   PANTHER; PTHR23032; PTHR23032; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Lipoprotein; Membrane; Methylation; Prenylation;
KW   Reference proteome.
FT   CHAIN           1..408
FT                   /note="BRO1 domain-containing protein BROX"
FT                   /id="PRO_0000304614"
FT   PROPEP          409..411
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000396738"
FT   DOMAIN          90..408
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          374..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        374..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         283
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5VW32"
FT   MOD_RES         408
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           408
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   411 AA;  46422 MW;  E99A6967F5683B63 CRC64;
     MTHWFHRNPL KATAPVSFNY YGVVTGPSAS KICNDLRSSR ARLLELFTDL SCNPEMMKNA
     ADSYFSLLQG FINSLDESTQ ESKLRYIQNF KWTDTLQGQV PSAQQDAVFE LISMGFNVAL
     WHTKYASRLA GKENITEDEA KEVHRSLKIA AGIFKHLKES HIPKLITPAE KGRDLESRLI
     EAYVIQCQAE AQEVTIARAI ELKHAPGLIA ALAYETANFY QKADHTLSSL EPAYSAKWRK
     YLHLKMCFYT AYAYCYHGET LLASDKCGEA IRSLQEAEKL YAKAEALCKE YGETKGPGPT
     VKPSGHLFFR KLGNLVKNTL EKCQRENGFI YFQKIPTEAP QLELKANYGL VEPIPFEFPP
     TSAQWTPETL AAFDLTKRPK DDSTKPKPEE EVKPVKEPDI KPQKDTGCYI S