ID   BROX_RAT                Reviewed;         411 AA.
AC   Q4V8K5;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=BRO1 domain-containing protein BROX;
DE   AltName: Full=BRO1 domain- and CAAX motif-containing protein;
DE   Flags: Precursor;
GN   Name=Brox;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with CHMP4B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BROX family. {ECO:0000305}.
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DR   EMBL; BC097348; AAH97348.1; -; mRNA.
DR   RefSeq; NP_001020840.1; NM_001025669.1.
DR   RefSeq; XP_017454324.1; XM_017598835.1.
DR   AlphaFoldDB; Q4V8K5; -.
DR   SMR; Q4V8K5; -.
DR   STRING; 10116.ENSRNOP00000004949; -.
DR   jPOST; Q4V8K5; -.
DR   PaxDb; Q4V8K5; -.
DR   PRIDE; Q4V8K5; -.
DR   Ensembl; ENSRNOT00000078834; ENSRNOP00000073617; ENSRNOG00000052963.
DR   GeneID; 305031; -.
DR   KEGG; rno:305031; -.
DR   CTD; 148362; -.
DR   RGD; 1307161; Brox.
DR   eggNOG; ENOG502QQBR; Eukaryota.
DR   GeneTree; ENSGT00390000006681; -.
DR   HOGENOM; CLU_056561_0_0_1; -.
DR   InParanoid; Q4V8K5; -.
DR   OMA; HTCLRRA; -.
DR   OrthoDB; 614228at2759; -.
DR   PhylomeDB; Q4V8K5; -.
DR   TreeFam; TF314743; -.
DR   PRO; PR:Q4V8K5; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000052963; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q4V8K5; RN.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR038898; BROX.
DR   PANTHER; PTHR23032; PTHR23032; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..408
FT                   /note="BRO1 domain-containing protein BROX"
FT                   /id="PRO_0000304615"
FT   PROPEP          409..411
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000396739"
FT   DOMAIN          90..408
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          376..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         408
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           408
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   411 AA;  46192 MW;  50FB82BD0FE31F76 CRC64;
     MTHWFHRNPL KATAPVSFNY YGMITGPPAS KICNDLRSAR TRLLELFTDL SCNPETMKNA
     ADLYFSLLQG FINSVGDSTQ ESKLRYIQNF KWTDTLQGHV PSAQQDAVFE LISMGFNVAL
     WYTKYASRLA GKENITEDEA KEVHRSLKIA AGIFKHLKES HIPKLLTPAE KGRDLEARLI
     DAYIIQCQAE AQEVTIARAI ELKHAPGLIA ALAYETASFY QKADHTLSSL EPAHSAKWRK
     YLHLKMCFYT AYAYCYHGQT LLASDKCGEA IRSLQEAEKL YAEAEALCKE YGETKGPGPT
     AKPSGHLFFR KLGSLVKNTL DKCQRENGFI YFQKIPTEAP QLELKANYGL VEPVPFEFPP
     MSALWTPEAL AAFDLTKRPK DDSIKPKPEE EVKPVKEPDI KPQKDTGCSV S