ID   BROX_XENTR              Reviewed;         411 AA.
AC   A4IIL4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=BRO1 domain-containing protein BROX;
DE   AltName: Full=BRO1 domain- and CAAX motif-containing protein;
DE   Flags: Precursor;
GN   Name=brox;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BROX family. {ECO:0000305}.
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DR   EMBL; BC136067; AAI36068.1; -; mRNA.
DR   RefSeq; NP_001096412.1; NM_001102942.1.
DR   RefSeq; XP_017949251.1; XM_018093762.1.
DR   AlphaFoldDB; A4IIL4; -.
DR   SMR; A4IIL4; -.
DR   STRING; 8364.ENSXETP00000032889; -.
DR   PaxDb; A4IIL4; -.
DR   DNASU; 100125017; -.
DR   GeneID; 100125017; -.
DR   KEGG; xtr:100125017; -.
DR   CTD; 148362; -.
DR   Xenbase; XB-GENE-5745545; brox.
DR   eggNOG; ENOG502QQBR; Eukaryota.
DR   HOGENOM; CLU_056561_0_0_1; -.
DR   InParanoid; A4IIL4; -.
DR   OrthoDB; 614228at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015033; Expressed in early embryo and 13 other tissues.
DR   ExpressionAtlas; A4IIL4; baseline.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.25.40.280; -; 1.
DR   InterPro; IPR004328; BRO1_dom.
DR   InterPro; IPR038499; BRO1_sf.
DR   InterPro; IPR038898; BROX.
DR   PANTHER; PTHR23032; PTHR23032; 1.
DR   Pfam; PF03097; BRO1; 1.
DR   SMART; SM01041; BRO1; 1.
DR   PROSITE; PS51180; BRO1; 1.
PE   2: Evidence at transcript level;
KW   Lipoprotein; Membrane; Methylation; Prenylation; Reference proteome.
FT   CHAIN           1..408
FT                   /note="BRO1 domain-containing protein BROX"
FT                   /id="PRO_0000304617"
FT   PROPEP          409..411
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000396741"
FT   DOMAIN          90..395
FT                   /note="BRO1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00526"
FT   REGION          362..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        373..403
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         408
FT                   /note="Cysteine methyl ester"
FT                   /evidence="ECO:0000250"
FT   LIPID           408
FT                   /note="S-farnesyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   411 AA;  46510 MW;  B2133B08E2F82764 CRC64;
     MTHWFHRNPL KATAPVSFNF YGVASTQAAS KICSDLRSTR ARLLELFSDI TCNHEMMKNA
     TDAYFSLLLG FIDSLDGGTQ DNKLRYIQNF KWTDTLQGNA PSAQQDAVFE LVSMGFNVAL
     WYTKYASRLA GKEDITEEEA KEVHRSLKIA AGVFKHLKEN HIPKLITPVE KGRDLETRVI
     DAYTVQCQAE AQEVTIARAI ELKHNPGLIA ALAYETANYY QKVDHTLATL DPVYIAKWRS
     YTQLKMCFYM AYSYCYHGQT LLSADKCGEA IRSLQEAEKF YGKAEALCKE YGETKGPGTT
     AKPSGHLFFR KMGTLVRNTL EKCQRENGFI YFQKVPPEAP QLELKANYGL VEPVPFEFPA
     MTSQWSPETH TGFDLTKRPK DDSAKPKKEE EVKPMKEPDI KPQKDSGCQI S