ID   BRPA_STRHY              Reviewed;         256 AA.
AC   Q01108;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Bialaphos biosynthetic pathway regulatory protein;
GN   Name=brpA;
OS   Streptomyces hygroscopicus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces violaceusniger group.
OX   NCBI_TaxID=1912;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HP460;
RX   PubMed=2066341; DOI=10.1128/jb.173.14.4454-4463.1991;
RA   Raibaud A., Zalacain M., Holt T.G., Tizard R., Thompson C.J.;
RT   "Nucleotide sequence analysis reveals linked N-acetyl hydrolase,
RT   thioesterase, transport, and regulatory genes encoded by the bialaphos
RT   biosynthetic gene cluster of Streptomyces hygroscopicus.";
RL   J. Bacteriol. 173:4454-4463(1991).
CC   -!- FUNCTION: Involved in the regulation of the bialaphos biosynthetic
CC       pathway.
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DR   EMBL; M64783; AAA79281.1; -; Genomic_DNA.
DR   PIR; F47031; F47031.
DR   AlphaFoldDB; Q01108; -.
DR   SMR; Q01108; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; DNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..256
FT                   /note="Bialaphos biosynthetic pathway regulatory protein"
FT                   /id="PRO_0000184141"
FT   DOMAIN          184..249
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        208..227
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   256 AA;  28219 MW;  24ABAB69FC2FAEEB CRC64;
     MTRLLSAHRK VVADQGRLLE ALESALGELV RSSPSRTDCS SLEAEQCAVG CFAMDPLVAA
     EGEVLLCLDP ADLEQERFSY LLECLHGAFL RGVTIRCICA ESMINLPGGR SYIQELQTAG
     AEIRVAPLLP FRLMLVDRIF ACVSVVDRHG ENSTLEIRSP ETCHFVHRVF DYCWVTRTSS
     KACETADAID VSDREVIILR LLANGMKDVA MARSLGISTR TLRRVITDLM GKLGVSSRFQ
     LGARAAECRL LWSVLS