ID   BRPA_STRMU              Reviewed;         406 AA.
AC   Q8DVR0;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Biofilm regulatory protein A;
DE   Flags: Precursor;
GN   Name=brpA; OrderedLocusNames=SMU_410;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN   [2]
RP   FUNCTION, CHARACTERIZATION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=11872468; DOI=10.1128/aem.68.3.1196-1203.2002;
RA   Wen Z.T., Burne R.A.;
RT   "Functional genomics approach to identifying genes required for biofilm
RT   development by Streptococcus mutans.";
RL   Appl. Environ. Microbiol. 68:1196-1203(2002).
RN   [3]
RP   REGULATION.
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=15090509; DOI=10.1128/jb.186.9.2682-2691.2004;
RA   Wen Z.T., Burne R.A.;
RT   "LuxS-mediated signaling in Streptococcus mutans is involved in regulation
RT   of acid and oxidative stress tolerance and biofilm formation.";
RL   J. Bacteriol. 186:2682-2691(2004).
RN   [4]
RP   FUNCTION, AND CHARACTERIZATION.
RC   STRAIN=MT8148 / Serotype c;
RX   PubMed=16039152; DOI=10.1016/j.micinf.2005.04.012;
RA   Nakano K., Fujita K., Nishimura K., Nomura R., Ooshima T.;
RT   "Contribution of biofilm regulatory protein A of Streptococcus mutans, to
RT   systemic virulence.";
RL   Microbes Infect. 7:1246-1255(2005).
RN   [5]
RP   FUNCTION, AND CHARACTERIZATION.
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=15699211; DOI=10.1099/mic.0.27604-0;
RA   Chatfield C.H., Koo H., Quivey R.G. Jr.;
RT   "The putative autolysin regulator LytR in Streptococcus mutans plays a role
RT   in cell division and is growth-phase regulated.";
RL   Microbiology 151:625-631(2005).
RN   [6]
RP   FUNCTION, AND CHARACTERIZATION.
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=16585759; DOI=10.1128/jb.188.8.2983-2992.2006;
RA   Wen Z.T., Baker H.V., Burne R.A.;
RT   "Influence of BrpA on critical virulence attributes of Streptococcus
RT   mutans.";
RL   J. Bacteriol. 188:2983-2992(2006).
CC   -!- FUNCTION: Involved in biofilm formation, cell division, autolysis and
CC       the regulation of acid and oxidative stress tolerance. May be
CC       associated with systemic virulence in blood.
CC       {ECO:0000269|PubMed:11872468, ECO:0000269|PubMed:15699211,
CC       ECO:0000269|PubMed:16039152, ECO:0000269|PubMed:16585759}.
CC   -!- SUBCELLULAR LOCATION: Cell envelope {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Cells form longer chains and sparse
CC       microcolonies, are more resistant to phagocytosis, show greater level
CC       of platelet aggregation, but are unable to form biofilm at least in
CC       vitro. {ECO:0000269|PubMed:11872468}.
CC   -!- MISCELLANEOUS: As a result of luxS inactivation, brpA expression was
CC       decreased by 70% in early-exponential-phase cells. Also, brpA
CC       expression was down-regulated in response to the deficiency of smu486
CC       and smu487.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
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DR   EMBL; AE014133; AAN58164.1; -; Genomic_DNA.
DR   RefSeq; NP_720858.1; NC_004350.2.
DR   RefSeq; WP_002262611.1; NC_004350.2.
DR   AlphaFoldDB; Q8DVR0; -.
DR   SMR; Q8DVR0; -.
DR   STRING; 210007.SMU_410; -.
DR   PRIDE; Q8DVR0; -.
DR   DNASU; 1029569; -.
DR   EnsemblBacteria; AAN58164; AAN58164; SMU_410.
DR   GeneID; 66818109; -.
DR   KEGG; smu:SMU_410; -.
DR   PATRIC; fig|210007.7.peg.360; -.
DR   eggNOG; COG1316; Bacteria.
DR   HOGENOM; CLU_016455_2_0_9; -.
DR   OMA; LLGYKDC; -.
DR   PhylomeDB; Q8DVR0; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0031975; C:envelope; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..406
FT                   /note="Biofilm regulatory protein A"
FT                   /id="PRO_0000251140"
FT   REGION          347..406
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  43909 MW;  E5455BA3E13E5A35 CRC64;
     MKIGKKILIM LVTIFLTSLV ALGVYATSIY NFSLGEFSKT FKDYGTGSGK DVIADEKPFS
     ILLMGVDTGS SERTSKWEGN SDSMILVTVN PKTKKTTMTS LERDILVKLS GSKTNDQTGY
     DAKLNAAYAA GGAKMAIMTV QDMLDIKIDK YVQINMEGLV QLVDAVGGIT VTNHFDFPIS
     IEEHEPEFTA SVEPGTHKIN GEQALVYSRM RYDDPDGDYG RQKRQREVIS KVLKKILALD
     SVSKYRKILS AVSKNMQTNI EISSSTIPKL LGYSDALKSI RTYQLKGEGT TIDGGSYQLV
     TSKELLKAQN RIKGQLGLKK STAENLKTTA SLYENFYGGD TSIYDSSSSA SDYSSSGNYS
     GSSSDYGSSS SYGSNSSSGS SSDYSGQNSY NQGNYQQPAA GTGIGN