ID   THIO2_NOSS1             Reviewed;         111 AA.
AC   P20857;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 139.
DE   RecName: Full=Thioredoxin 2;
DE            Short=Thioredoxin-2 {ECO:0000303|PubMed:8590004};
DE            Short=Trx-2;
GN   Name=trxB; OrderedLocusNames=all2341;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=2492494; DOI=10.1128/jb.171.1.162-171.1989;
RA   Alam J., Curtis S.E., Gleason F.K., Gerami-Nejad M., Fuchs J.A.;
RT   "Isolation, sequence, and expression in Escherichia coli of an unusual
RT   thioredoxin gene from the cyanobacterium Anabaena sp. strain PCC 7120.";
RL   J. Bacteriol. 171:162-171(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS), AND DISULFIDE BOND.
RX   PubMed=8590004; DOI=10.1016/s0969-2126(01)00245-3;
RA   Saarinen M., Gleason F.K., Eklund H.;
RT   "Crystal structure of thioredoxin-2 from Anabaena.";
RL   Structure 3:1097-1108(1995).
CC   -!- FUNCTION: Participates in various redox reactions through the
CC       reversible oxidation of its active center dithiol to a disulfide and
CC       catalyzes dithiol-disulfide exchange reactions.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB74040.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; M22997; AAA22048.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB74040.1; ALT_INIT; Genomic_DNA.
DR   PIR; A32233; A32233.
DR   PIR; AF2098; AF2098.
DR   RefSeq; WP_044521338.1; NZ_RSCN01000004.1.
DR   PDB; 1THX; X-ray; 1.60 A; A=1-111.
DR   PDBsum; 1THX; -.
DR   AlphaFoldDB; P20857; -.
DR   SMR; P20857; -.
DR   STRING; 103690.17131433; -.
DR   EnsemblBacteria; BAB74040; BAB74040; BAB74040.
DR   KEGG; ana:all2341; -.
DR   eggNOG; COG3118; Bacteria.
DR   OMA; HEGAITK; -.
DR   OrthoDB; 1630944at2; -.
DR   EvolutionaryTrace; P20857; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0015035; F:protein-disulfide reductase activity; IEA:InterPro.
DR   InterPro; IPR005746; Thioredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PIRSF; PIRSF000077; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..111
FT                   /note="Thioredoxin 2"
FT                   /id="PRO_0000120075"
FT   DOMAIN          2..109
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        33..36
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691,
FT                   ECO:0000269|PubMed:8590004"
FT   STRAND          4..7
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   HELIX           10..12
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   HELIX           13..16
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   TURN            17..19
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   STRAND          24..29
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   HELIX           36..49
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   TURN            50..53
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   STRAND          55..61
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   HELIX           65..70
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   STRAND          75..83
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   STRAND          86..93
FT                   /evidence="ECO:0007829|PDB:1THX"
FT   HELIX           97..108
FT                   /evidence="ECO:0007829|PDB:1THX"
SQ   SEQUENCE   111 AA;  12366 MW;  9796605A3A14A21D CRC64;
     MSKGVITITD AEFESEVLKA EQPVLVYFWA SWCGPCQLMS PLINLAANTY SDRLKVVKLE
     IDPNPTTVKK YKVEGVPALR LVKGEQILDS TEGVISKDKL LSFLDTHLNN N