ID   THIO_ACIFI              Reviewed;         108 AA.
AC   P52233;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Thioredoxin;
DE            Short=Trx;
GN   Name=trxA;
OS   Acidithiobacillus ferridurans.
OC   Bacteria; Proteobacteria; Acidithiobacillia; Acidithiobacillales;
OC   Acidithiobacillaceae; Acidithiobacillus.
OX   NCBI_TaxID=1232575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33020 / DSM 29468 / JCM 18981 / 11Fe;
RX   PubMed=7496529; DOI=10.1099/13500872-141-9-2175;
RA   Powles R.E., Deane S.M., Rawlings D.E.;
RT   "Molecular genetic analysis of a thioredoxin gene from Thiobacillus
RT   ferrooxidans.";
RL   Microbiology 141:2175-2181(1995).
CC   -!- FUNCTION: Component of the thioredoxin-thioredoxin reductase system.
CC       Participates in various redox reactions through the reversible
CC       oxidation of its active center dithiol to a disulfide and catalyzes
CC       dithiol-disulfide exchange reactions.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; U20361; AAA88939.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52233; -.
DR   SMR; P52233; -.
DR   STRING; 380394.Lferr_0806; -.
DR   PRIDE; P52233; -.
DR   GO; GO:0015035; F:protein-disulfide reductase activity; IEA:InterPro.
DR   InterPro; IPR005746; Thioredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PIRSF; PIRSF000077; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01068; thioredoxin; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Electron transport; Redox-active center; Transport.
FT   CHAIN           1..108
FT                   /note="Thioredoxin"
FT                   /id="PRO_0000120142"
FT   DOMAIN          2..108
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        33..36
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   108 AA;  11979 MW;  76200C2FF2AD067F CRC64;
     MSDAILYVSD DSFETDVLKS SKPVLVDFWA EWCGPCKMIA PILEEIADEY ADRLRVAKFN
     IDENPNTPPQ YAIRGIPTLL LFKAGKLEAT KVGALSKAQL TAFLDSQL