ID   THIO_BUCAI              Reviewed;         108 AA.
AC   P57653;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Thioredoxin;
DE            Short=Trx;
GN   Name=trxA; OrderedLocusNames=BU597;
OS   Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon
OS   pisum symbiotic bacterium).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Buchnera.
OX   NCBI_TaxID=107806;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APS;
RX   PubMed=10993077; DOI=10.1038/35024074;
RA   Shigenobu S., Watanabe H., Hattori M., Sakaki Y., Ishikawa H.;
RT   "Genome sequence of the endocellular bacterial symbiont of aphids Buchnera
RT   sp. APS.";
RL   Nature 407:81-86(2000).
CC   -!- FUNCTION: Participates in various redox reactions through the
CC       reversible oxidation of its active center dithiol to a disulfide and
CC       catalyzes dithiol-disulfide exchange reactions.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; BA000003; BAB13282.1; -; Genomic_DNA.
DR   RefSeq; NP_240396.1; NC_002528.1.
DR   RefSeq; WP_009874545.1; NC_002528.1.
DR   AlphaFoldDB; P57653; -.
DR   SMR; P57653; -.
DR   STRING; 107806.10039248; -.
DR   EnsemblBacteria; BAB13282; BAB13282; BAB13282.
DR   KEGG; buc:BU597; -.
DR   PATRIC; fig|107806.10.peg.600; -.
DR   eggNOG; COG3118; Bacteria.
DR   HOGENOM; CLU_090389_10_4_6; -.
DR   OMA; QVGVAPK; -.
DR   Proteomes; UP000001806; Chromosome.
DR   GO; GO:0015035; F:protein-disulfide reductase activity; IEA:InterPro.
DR   InterPro; IPR005746; Thioredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PIRSF; PIRSF000077; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01068; thioredoxin; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..108
FT                   /note="Thioredoxin"
FT                   /id="PRO_0000120078"
FT   DOMAIN          2..108
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        32..35
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   108 AA;  12347 MW;  703632A814DFA257 CRC64;
     MNKIIELTDQ NFEEQVLNSK SFFLVDFWAQ WCNPCKILAP ILEEISKEYS NKVIVGKLNI
     EENPNTAPVY SIRSIPTLLL FNNSEVLATK VGAVSKLELK EFLDENIN