ID   BRR1_ASHGO              Reviewed;         322 AA.
AC   Q75B95;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Pre-mRNA-splicing factor BRR1;
GN   Name=BRR1; OrderedLocusNames=ADL325C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in mRNA splicing. Required for snRNA accumulation
CC       and manufacture of snRNPs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BRR1 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51595.1; -; Genomic_DNA.
DR   RefSeq; NP_983771.1; NM_209124.1.
DR   AlphaFoldDB; Q75B95; -.
DR   SMR; Q75B95; -.
DR   STRING; 33169.AAS51595; -.
DR   EnsemblFungi; AAS51595; AAS51595; AGOS_ADL325C.
DR   GeneID; 4619906; -.
DR   KEGG; ago:AGOS_ADL325C; -.
DR   eggNOG; ENOG502S02X; Eukaryota.
DR   HOGENOM; CLU_748374_0_0_1; -.
DR   InParanoid; Q75B95; -.
DR   OMA; NEPSHSI; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0030532; C:small nuclear ribonucleoprotein complex; IEA:InterPro.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:InterPro.
DR   InterPro; IPR023251; Brr1.
DR   InterPro; IPR035426; Gemin2/Brr1.
DR   Pfam; PF04938; SIP1; 1.
DR   PRINTS; PR02039; SPLICEFRBRR1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..322
FT                   /note="Pre-mRNA-splicing factor BRR1"
FT                   /id="PRO_0000239635"
SQ   SEQUENCE   322 AA;  36701 MW;  8DDAA0703DCB4E18 CRC64;
     MGHTSGPVDP VFGQCQVFDC SAAEVNPEVV KYLAHVRDEA LHTVGVVPSA SNLRKRKIEI
     SYDDEEVVKR PSEGEKAIEL PFDMDEVISW FDQVKEDALS EREAFEGYDE ETLNTLLVGI
     RDYISRMSSR DESTNNLIKL LEGVQPVVTN EALELDEKWA AKLVARLGRR KFTTLDNLKL
     RLNTQLPIPT RAKAWKIHIP INEPSHEFFH RMNSTQLFDL LRYLTDNIVE HYQTDSATDY
     GQWLVYLLLH LPRQLTANEI SEVRGLSKKV RALIIDHEIL KLPMLLPSEI EDVSPIPRGV
     NPLHLALAVV AVIYGQRDIL FL