ID   THIO_FUSCU              Reviewed;         121 AA.
AC   Q8TFM8;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Thioredoxin-like protein;
DE   AltName: Allergen=Fus c 2;
OS   Fusarium culmorum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=5516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=12695122; DOI=10.1016/s0161-5890(03)00026-9;
RA   Hoff M., Ballmer-Weber B.K., Niggemann B., Cistero-Bahima A.,
RA   San Miguel-Moncin M., Conti A., Haustein D., Vieths S.;
RT   "Molecular cloning and immunological characterisation of potential
RT   allergens from the mould Fusarium culmorum.";
RL   Mol. Immunol. 39:965-975(2003).
CC   -!- FUNCTION: Participates in various redox reactions through the
CC       reversible oxidation of its active center dithiol to a disulfide and
CC       catalyzes dithiol-disulfide exchange reactions.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC       {ECO:0000269|PubMed:12695122}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; AY077707; AAL79931.1; -; mRNA.
DR   AlphaFoldDB; Q8TFM8; -.
DR   SMR; Q8TFM8; -.
DR   Allergome; 3289; Fus c 2.0101.
DR   Allergome; 701; Fus c 2.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Disulfide bond; Electron transport; Redox-active center;
KW   Transport.
FT   CHAIN           1..121
FT                   /note="Thioredoxin-like protein"
FT                   /id="PRO_0000120040"
FT   DOMAIN          2..112
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        30..33
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   121 AA;  13017 MW;  BA1008F8383C3F71 CRC64;
     MVHHITSNDE LQKLLSSTTY VVVDFFADWC PPCKAIAPVY EQLSTKHSVP DVLAFAKVNV
     DHVQDAAQQY GITAMPTFMF FKEGKQVAVN GQAVIKGADP RTLGAAAEKL GGLAQKRVAG
     A