ID   THIO_HELPY              Reviewed;         106 AA.
AC   P66928; P56430;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Thioredoxin;
DE            Short=Trx;
GN   Name=trxA; OrderedLocusNames=HP_0824;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Participates in various redox reactions through the
CC       reversible oxidation of its active center dithiol to a disulfide and
CC       catalyzes dithiol-disulfide exchange reactions. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07874.1; -; Genomic_DNA.
DR   PIR; H64622; H64622.
DR   RefSeq; NP_207617.1; NC_000915.1.
DR   RefSeq; WP_000020199.1; NC_018939.1.
DR   PDB; 6BKV; X-ray; 2.35 A; A/B=1-106.
DR   PDBsum; 6BKV; -.
DR   AlphaFoldDB; P66928; -.
DR   SMR; P66928; -.
DR   IntAct; P66928; 3.
DR   STRING; 85962.C694_04220; -.
DR   PaxDb; P66928; -.
DR   EnsemblBacteria; AAD07874; AAD07874; HP_0824.
DR   KEGG; hpy:HP_0824; -.
DR   PATRIC; fig|85962.47.peg.878; -.
DR   eggNOG; COG3118; Bacteria.
DR   OMA; KIKICKF; -.
DR   PhylomeDB; P66928; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0015035; F:protein-disulfide reductase activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IBA:GO_Central.
DR   InterPro; IPR005746; Thioredoxin.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   PIRSF; PIRSF000077; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR01068; thioredoxin; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Electron transport; Redox-active center;
KW   Reference proteome; Transport.
FT   CHAIN           1..106
FT                   /note="Thioredoxin"
FT                   /id="PRO_0000120108"
FT   DOMAIN          2..106
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        30..33
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   STRAND          4..6
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   TURN            9..11
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   HELIX           12..16
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   STRAND          17..26
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   HELIX           31..46
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   TURN            47..50
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   STRAND          51..57
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   TURN            58..60
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   HELIX           62..67
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   STRAND          72..80
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   STRAND          83..91
FT                   /evidence="ECO:0007829|PDB:6BKV"
FT   HELIX           94..104
FT                   /evidence="ECO:0007829|PDB:6BKV"
SQ   SEQUENCE   106 AA;  11855 MW;  0616F0DC47695967 CRC64;
     MSHYIELTEE NFESTIKKGV ALVDFWAPWC GPCKMLSPVI DELASEYEGK AKICKVNTDE
     QEELSAKFGI RSIPTLLFTK DGEVVHQLVG VQTKVALKEQ LNKLLG