ID   THIO_METJA              Reviewed;          85 AA.
AC   Q57755;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 129.
DE   RecName: Full=Thioredoxin;
GN   Name=trx; OrderedLocusNames=MJ0307;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   FUNCTION, AND STRUCTURE BY NMR.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=10828983; DOI=10.1021/bi000035b;
RA   Lee D.Y., Ahn B.-Y., Kim K.-S.;
RT   "A thioredoxin from the hyperthermophilic archaeon Methanococcus jannaschii
RT   has a glutaredoxin-like fold but thioredoxin-like activities.";
RL   Biochemistry 39:6652-6659(2000).
CC   -!- FUNCTION: Acts to maintain redox homeostasis; functions as a protein
CC       disulfide reductase. {ECO:0000269|PubMed:10828983}.
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Redox potential:
CC         E(0) is -277 mV.;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glutaredoxin family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98293.1; -; Genomic_DNA.
DR   PIR; D64338; D64338.
DR   RefSeq; WP_010869805.1; NC_000909.1.
DR   PDB; 1FO5; NMR; -; A=1-85.
DR   PDBsum; 1FO5; -.
DR   AlphaFoldDB; Q57755; -.
DR   BMRB; Q57755; -.
DR   SMR; Q57755; -.
DR   STRING; 243232.MJ_0307; -.
DR   EnsemblBacteria; AAB98293; AAB98293; MJ_0307.
DR   GeneID; 1451162; -.
DR   KEGG; mja:MJ_0307; -.
DR   eggNOG; arCOG01972; Archaea.
DR   HOGENOM; CLU_090389_20_2_2; -.
DR   InParanoid; Q57755; -.
DR   OMA; YGIMAVP; -.
DR   OrthoDB; 110723at2157; -.
DR   PhylomeDB; Q57755; -.
DR   EvolutionaryTrace; Q57755; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0004362; F:glutathione-disulfide reductase (NADPH) activity; IEA:InterPro.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   InterPro; IPR011767; GLR_AS.
DR   InterPro; IPR004502; Thio_glut.
DR   InterPro; IPR012336; Thioredoxin-like_fold.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF13192; Thioredoxin_3; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   TIGRFAMs; TIGR00411; redox_disulf_1; 1.
DR   PROSITE; PS00195; GLUTAREDOXIN_1; 1.
DR   PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Disulfide bond; Electron transport;
KW   Redox-active center; Reference proteome; Transport.
FT   CHAIN           1..85
FT                   /note="Thioredoxin"
FT                   /id="PRO_0000141645"
FT   DOMAIN          1..85
FT                   /note="Glutaredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT   DISULFID        14..17
FT                   /note="Redox-active"
FT   STRAND          4..10
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   HELIX           20..30
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   STRAND          32..45
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   TURN            48..50
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   TURN            52..54
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   STRAND          57..62
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   STRAND          65..67
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   STRAND          70..74
FT                   /evidence="ECO:0007829|PDB:1FO5"
FT   HELIX           75..84
FT                   /evidence="ECO:0007829|PDB:1FO5"
SQ   SEQUENCE   85 AA;  9404 MW;  A38309843CD81A2D CRC64;
     MSKVKIELFT SPMCPHCPAA KRVVEEVANE MPDAVEVEYI NVMENPQKAM EYGIMAVPTI
     VINGDVEFIG APTKEALVEA IKKRL