BRR6_YEAST
ID BRR6_YEAST Reviewed; 197 AA.
AC P53062; D6VV88;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Nucleus export protein BRR6;
DE AltName: Full=Bad response to refrigeration protein 6;
GN Name=BRR6; OrderedLocusNames=YGL247W; ORFNames=NRA197;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972578;
RX DOI=10.1002/(sici)1097-0061(199612)12:15<1555::aid-yea43>3.0.co;2-q;
RA Coissac E., Maillier E., Robineau S., Netter P.;
RT "Sequence of a 39,411 bp DNA fragment covering the left end of chromosome
RT VII of Saccharomyces cerevisiae.";
RL Yeast 12:1555-1562(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169869;
RA Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
RA Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
RA Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
RA Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
RA Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
RA Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
RA Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
RA Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
RA Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
RA Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
RA Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
RA Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
RA Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
RA Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
RA Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
RA Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
RA Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
RA Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
RA Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
RA Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
RA Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
RA Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
RL Nature 387:81-84(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=11483521; DOI=10.1093/emboj/20.15.4183;
RA de Bruyn Kops A., Guthrie C.;
RT "An essential nuclear envelope integral membrane protein, Brr6p, required
RT for nuclear transport.";
RL EMBO J. 20:4183-4193(2001).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP FUNCTION, AND INTERACTION WITH BRL1.
RX PubMed=15882446; DOI=10.1111/j.1600-0854.2005.00295.x;
RA Saitoh Y.-H., Ogawa K., Nishimoto T.;
RT "Brl1p - a novel nuclear envelope protein required for nuclear transport.";
RL Traffic 6:502-517(2005).
CC -!- FUNCTION: Required for mRNA nuclear export. Involved in the nuclear
CC pore complex (NPC) distribution and nuclear envelope morphology.
CC {ECO:0000269|PubMed:11483521, ECO:0000269|PubMed:15882446}.
CC -!- SUBUNIT: Interacts with BRL1. {ECO:0000269|PubMed:15882446}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:11483521,
CC ECO:0000269|PubMed:14562095}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11483521, ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 125 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the BRL1/BRR6 family. {ECO:0000305}.
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DR EMBL; X94357; CAA64140.1; -; Genomic_DNA.
DR EMBL; Z72769; CAA96967.1; -; Genomic_DNA.
DR EMBL; AY693171; AAT93190.1; -; Genomic_DNA.
DR EMBL; BK006941; DAA07872.1; -; Genomic_DNA.
DR PIR; S61614; S61614.
DR RefSeq; NP_011267.1; NM_001181113.1.
DR AlphaFoldDB; P53062; -.
DR BioGRID; 33032; 361.
DR DIP; DIP-7322N; -.
DR IntAct; P53062; 1.
DR STRING; 4932.YGL247W; -.
DR TCDB; 9.A.34.1.1; the nuclear pore complex biogenesis (npc-b) family.
DR PaxDb; P53062; -.
DR PRIDE; P53062; -.
DR EnsemblFungi; YGL247W_mRNA; YGL247W; YGL247W.
DR GeneID; 852645; -.
DR KEGG; sce:YGL247W; -.
DR SGD; S000003216; BRR6.
DR VEuPathDB; FungiDB:YGL247W; -.
DR eggNOG; KOG4503; Eukaryota.
DR HOGENOM; CLU_107711_0_0_1; -.
DR InParanoid; P53062; -.
DR OMA; FGSYRVY; -.
DR BioCyc; YEAST:G3O-30718-MON; -.
DR PRO; PR:P53062; -.
DR Proteomes; UP000002311; Chromosome VII.
DR RNAct; P53062; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005635; C:nuclear envelope; IDA:SGD.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055088; P:lipid homeostasis; IMP:SGD.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006998; P:nuclear envelope organization; IMP:SGD.
DR InterPro; IPR040202; Brl1/Brr6.
DR InterPro; IPR018767; Brl1/Brr6_dom.
DR PANTHER; PTHR28136; PTHR28136; 1.
DR Pfam; PF10104; Brr6_like_C_C; 1.
DR SMART; SM01042; Brr6_like_C_C; 1.
PE 1: Evidence at protein level;
KW Membrane; mRNA transport; Nucleus; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..197
FT /note="Nucleus export protein BRR6"
FT /id="PRO_0000202707"
FT TRANSMEM 54..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 22807 MW; 92326642C0C9439E CRC64;
MELRSFSRQP DGILANPRLG REEVLEGEHP QDARLARQSI WLSPSLIAEY IQLFFNFIIG
TIGLSLAIKF ILMIRNDVNL KLEHNVREEL DKIATCKSRY FENQCEPHMR VPALEVRCNE
WSKCMNKEIV SGSDYQWAKA WARTLAEVIN AFFEAFSIRS FLFILISIIG IIFVTNTSFG
SYRVYLNNKD TKSVRHA
