ID   BRRF1_EBVB9             Reviewed;         310 AA.
AC   P03207; Q777E3;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Transcriptional activator BRRF1;
GN   ORFNames=BRRF1;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   FUNCTION.
RX   PubMed=15113878; DOI=10.1128/jvi.78.10.4983-4992.2004;
RA   Hong G.K., Delecluse H.J., Gruffat H., Morrison T.E., Feng W.H.,
RA   Sergeant A., Kenney S.C.;
RT   "The BRRF1 early gene of Epstein-Barr virus encodes a transcription factor
RT   that enhances induction of lytic infection by BRLF1.";
RL   J. Virol. 78:4983-4992(2004).
CC   -!- FUNCTION: Enhances the ability of BRLF1 to induce lytic infection by
CC       cooperating with it to transcriptionally activate the BZLF1 promoter.
CC       {ECO:0000269|PubMed:15113878}.
CC   -!- SIMILARITY: Belongs to the lymphocryptovirus BBRF1 family.
CC       {ECO:0000305}.
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DR   EMBL; V01555; CAA24813.1; -; Genomic_DNA.
DR   EMBL; AJ507799; CAD53425.1; -; Genomic_DNA.
DR   PIR; H43042; QQBE28.
DR   RefSeq; YP_401675.1; NC_007605.1.
DR   SMR; P03207; -.
DR   BioGRID; 971770; 2.
DR   IntAct; P03207; 3.
DR   MINT; P03207; -.
DR   PRIDE; P03207; -.
DR   DNASU; 3783728; -.
DR   GeneID; 3783728; -.
DR   KEGG; vg:3783728; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0019046; P:release from viral latency; IMP:CACAO.
DR   InterPro; IPR006878; Herpes_BBRF1.
DR   Pfam; PF04793; Herpes_BBRF1; 1.
PE   3: Inferred from homology;
KW   Early protein; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..310
FT                   /note="Transcriptional activator BRRF1"
FT                   /id="PRO_0000116258"
SQ   SEQUENCE   310 AA;  35319 MW;  05F8A4719F604D03 CRC64;
     MASSNRGNAR PLKSFLHELY LKHYPEVGDV VHLLNTIGVD CDLPPSHPLL TAQRGLFLAR
     VLQAVQQHKL LEDTIVPKIL KKLAYFLELL SYYSPKDEQR DIAEVLDHLK TNRDLGLDDR
     LWALIRKLRQ DRHHASVNVL MPGSDYTAVS LQYYDGISIG MRKVIADVCR SGYASMPSMT
     ATHNLSHQLL MASGPSEEPC AWRGFFNQVL LWTVALCKFR RCIYYNYIQG SIATISQLLH
     LEIKALCSWI ISQDGMRLFQ HSRPLLTLWE SVAANQEVTD AITLPDCAEY IDLLKHTKHV
     LENCSAMQYK