THIP_HAEIN
ID THIP_HAEIN Reviewed; 538 AA.
AC P44985;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Thiamine transport system permease protein ThiP;
GN Name=thiP; OrderedLocusNames=HI_1020;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Part of the ABC transporter complex ThiBPQ involved in
CC thiamine import. Probably responsible for the translocation of the
CC substrate across the membrane. {ECO:0000250|UniProtKB:Q8ZRV1}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (ThiQ),
CC two transmembrane proteins (ThiP) and a solute-binding protein (ThiB).
CC {ECO:0000250|UniProtKB:Q8ZRV1}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P31549}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. CysTW subfamily. {ECO:0000305}.
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DR EMBL; L42023; AAC22679.1; -; Genomic_DNA.
DR PIR; D64164; D64164.
DR RefSeq; NP_439180.1; NC_000907.1.
DR RefSeq; WP_005693357.1; NC_000907.1.
DR AlphaFoldDB; P44985; -.
DR SMR; P44985; -.
DR STRING; 71421.HI_1020; -.
DR EnsemblBacteria; AAC22679; AAC22679; HI_1020.
DR KEGG; hin:HI_1020; -.
DR PATRIC; fig|71421.8.peg.1064; -.
DR eggNOG; COG1178; Bacteria.
DR HOGENOM; CLU_021838_5_3_6; -.
DR OMA; PLYLFQL; -.
DR PhylomeDB; P44985; -.
DR BioCyc; HINF71421:G1GJ1-1060-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015888; P:thiamine transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 2.
DR Gene3D; 1.10.3720.10; -; 2.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR InterPro; IPR005947; ThiP_ABC_transpt.
DR Pfam; PF00528; BPD_transp_1; 2.
DR SUPFAM; SSF161098; SSF161098; 2.
DR TIGRFAMs; TIGR01253; thiP; 1.
DR PROSITE; PS50928; ABC_TM1; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..538
FT /note="Thiamine transport system permease protein ThiP"
FT /id="PRO_0000060231"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 466..486
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 509..529
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 58..263
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 333..528
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 538 AA; 60851 MW; D7B31D2A15BCD6E1 CRC64;
MFSLFHHPQL RPRHYAGGVV VISFIILFYG GALSSIFALG GELQWRAWFT DDYLQHLILF
SFGQALLSTV LSIFFGLLLA RALFYKPFLG KKWLLKLMSL TFVLPALVVI FGLIGIYGSS
GWLAWLANLF GMSWQGHIYG LSGILIAHLF FNIPLAAQLF LQSLQSIPYQ QRQLAAQLNL
QGWQFVKLVE WPVFRQQCLP TFSLIFMLCF TSFTVVLTLG GGPQYTTLET AIYQAILFEF
DLPKAALFAM LQFVFCLILF SLTSRFSLSN QNGLSNSNIW FEKPKSAVKI FHILVLLVFV
FFLFSPVLNI LISALSSSNL LTVWHNSQLW RALGYSLSIA PLSALLALTM AIALLLLSRR
LEWLHYQKIS QFIINAGMVI LAIPILVLAM GLFLLLQDRD FSNIDLFIIV VFCNALSAMP
FVLRILSAPF HNNMRYYENL CNSLGIVGWQ RFYLIEWKTL RAPLRYAFAL GLALSLGDFT
AIALFGNQEF TSLPHLLYQQ LGNYRNQDAA VTAGILLLLC GILFAFIHTY RDADDLSK
