BRS3_CAVPO
ID BRS3_CAVPO Reviewed; 399 AA.
AC P35371;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Bombesin receptor subtype-3;
DE Short=BRS-3;
GN Name=BRS3;
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Uterus;
RX PubMed=1325907; DOI=10.1111/j.1432-1033.1992.tb17201.x;
RA Gorbulev V., Akhundova A., Buechner H., Fahrenholz F.;
RT "Molecular cloning of a new bombesin receptor subtype expressed in uterus
RT during pregnancy.";
RL Eur. J. Biochem. 208:405-410(1992).
CC -!- FUNCTION: Role in sperm cell division, maturation, or function. The
CC relative order of ligand affinity is GRP = neuromedin-C >> neuromedin-
CC B. This receptor mediates its action by association with G proteins
CC that activate a phosphatidylinositol-calcium second messenger system.
CC -!- SUBUNIT: Interacts with C6orf89. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Mainly in uteri of pregnant animals.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; X67126; CAA47605.1; -; mRNA.
DR PIR; S29480; S29480.
DR RefSeq; NP_001166392.1; NM_001172921.1.
DR AlphaFoldDB; P35371; -.
DR SMR; P35371; -.
DR STRING; 10141.ENSCPOP00000012930; -.
DR Ensembl; ENSCPOT00000014498; ENSCPOP00000012930; ENSCPOG00000014354.
DR GeneID; 100135488; -.
DR KEGG; cpoc:100135488; -.
DR CTD; 680; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244862; -.
DR HOGENOM; CLU_009579_6_2_1; -.
DR InParanoid; P35371; -.
DR OMA; HFIVTIF; -.
DR OrthoDB; 1153238at2759; -.
DR TreeFam; TF331292; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000014354; Expressed in heart and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004946; F:bombesin receptor activity; IEA:InterPro.
DR InterPro; IPR001560; Bombesin_rcpt_3.
DR InterPro; IPR001556; Bombsn_rcpt-like.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00637; BOMBESIN3R.
DR PRINTS; PR00358; BOMBESINR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..399
FT /note="Bombesin receptor subtype-3"
FT /id="PRO_0000069195"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..163
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..220
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..272
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..313
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..399
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 347
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..203
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 399 AA; 44342 MW; 19B75D027AB9A0DE CRC64;
MSQKQPQSPN QTLISITNDT ESSSSVVSND TTNKGWTGDN SPGIEALCAI YITYAVIISV
GILGNAILIK VFFKTKSMQT VPNIFITSLA LGDLLLLLTC VPVDATHYLA EGWLFGRIGC
KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCAKAGC IWIMSMIFAL
PEAIFSNVHT LRDPNKNMTS EWCAFYPVSE KLLQEIHALL SFLVFYIIPL SIISVYYSLI
ARTLYKSTLN IPTEEQSHAR KQVESRKRIA KTVLVLVALF ALCWLPNHLL NLYHSFTHKA
YEDSSAIHFI VTIFSRVLAF SNSCVNPFAL YWLSKTFQKQ FKAQLFCCKG ELPEPPLAAT
PLNSLAVMGR VSGTENTHIS EIGVASFIGR PMKKEENRV
