ID   THIX_HAEIN              Reviewed;         167 AA.
AC   P43787;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Thioredoxin-like protein HI_1115;
GN   OrderedLocusNames=HI_1115;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22769.1; -; Genomic_DNA.
DR   PIR; G64183; G64183.
DR   RefSeq; NP_439272.1; NC_000907.1.
DR   RefSeq; WP_005693438.1; NC_000907.1.
DR   AlphaFoldDB; P43787; -.
DR   SMR; P43787; -.
DR   STRING; 71421.HI_1115; -.
DR   PRIDE; P43787; -.
DR   EnsemblBacteria; AAC22769; AAC22769; HI_1115.
DR   KEGG; hin:HI_1115; -.
DR   PATRIC; fig|71421.8.peg.1164; -.
DR   eggNOG; COG0526; Bacteria.
DR   HOGENOM; CLU_042529_10_1_6; -.
DR   OMA; YVWATWC; -.
DR   PhylomeDB; P43787; -.
DR   BioCyc; HINF71421:G1GJ1-1150-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016209; F:antioxidant activity; IEA:InterPro.
DR   GO; GO:0015036; F:disulfide oxidoreductase activity; IEA:UniProt.
DR   InterPro; IPR000866; AhpC/TSA.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00578; AhpC-TSA; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Membrane; Redox-active center;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..167
FT                   /note="Thioredoxin-like protein HI_1115"
FT                   /id="PRO_0000120180"
FT   TRANSMEM        10..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          30..167
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        69..72
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   167 AA;  19034 MW;  1AF6FAF9AE5FD23E CRC64;
     MKIKKLLKNG LSLFLTFIVI TSILDFVRRP VVPEEINKIT LQDLQGNTFS LESLDQNKPT
     LLYFWGTWCG YCRYTSPAIN SLAKEGYQVV SVALRSGNEA DVNDYLSKND YHFTTVNDPK
     GEFAERWQIN VTPTIVLLSK GKMDLVTTGL TSYWGLKVRL FFAEFFG