ID   THLA_CLOPA              Reviewed;          15 AA.
AC   P81347;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Acetyl-CoA acetyltransferase {ECO:0000250|UniProtKB:P45359};
DE            EC=2.3.1.9 {ECO:0000250|UniProtKB:P45359};
DE   AltName: Full=Acetoacetyl-CoA thiolase {ECO:0000250|UniProtKB:P45359};
DE   AltName: Full=CP 13;
DE   Flags: Fragment;
GN   Name=thl;
OS   Clostridium pasteurianum.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1501;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=ATCC 6013 / DSM 525 / NCIB 9486 / VKM B-1774 / W5;
RX   PubMed=9629918; DOI=10.1002/elps.1150190533;
RA   Flengsrud R., Skjeldal L.;
RT   "Two-dimensional gel electrophoresis separation and N-terminal sequence
RT   analysis of proteins from Clostridium pasteurianum W5.";
RL   Electrophoresis 19:802-806(1998).
CC   -!- FUNCTION: Catalyzes the condensation of two molecules of acetyl-CoA to
CC       produce acetoacetyl-CoA. {ECO:0000250|UniProtKB:P45359}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 acetyl-CoA = acetoacetyl-CoA + CoA; Xref=Rhea:RHEA:21036,
CC         ChEBI:CHEBI:57286, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.9;
CC         Evidence={ECO:0000250|UniProtKB:P45359};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250|UniProtKB:P45359}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P45359}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000305}.
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DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Acyltransferase; Cytoplasm; Direct protein sequencing; Transferase.
FT   CHAIN           1..>15
FT                   /note="Acetyl-CoA acetyltransferase"
FT                   /id="PRO_0000206405"
FT   NON_TER         15
SQ   SEQUENCE   15 AA;  1498 MW;  9735820D61BB35FC CRC64;
     MKEVVIASAV XTAXG