THM1_THADA
ID THM1_THADA Reviewed; 235 AA.
AC P02883; A1IIJ1; Q8RVT0;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Thaumatin I {ECO:0000303|PubMed:456365};
DE AltName: Full=Thaumatin-1 {ECO:0000305};
DE Flags: Precursor;
OS Thaumatococcus daniellii (Katemfe) (Phrynium daniellii).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Marantaceae;
OC Thaumatococcus.
OX NCBI_TaxID=4621;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=17897626; DOI=10.1016/j.bbrc.2007.09.021;
RA Ide N., Masuda T., Kitabatake N.;
RT "Effects of pre- and pro-sequence of thaumatin on the secretion by Pichia
RT pastoris.";
RL Biochem. Biophys. Res. Commun. 363:708-714(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 23-229.
RX PubMed=17691810; DOI=10.1021/bp070072v;
RA Ide N., Kaneko R., Wada R., Mehta A., Tamaki S., Tsuruta T., Fujita Y.,
RA Masuda T., Kitabatake N.;
RT "Cloning of the thaumatin I cDNA and characterization of recombinant
RT thaumatin I secreted by Pichia pastoris.";
RL Biotechnol. Prog. 23:1023-1030(2007).
RN [3]
RP PROTEIN SEQUENCE OF 23-229.
RX PubMed=456365; DOI=10.1111/j.1432-1033.1979.tb13029.x;
RA Iyengar R.B., Smits P., van der Ouderaa F., van der Wel H.,
RA van Brouwershaven J., Ravestein P., Richters G., van Wassenaar P.D.;
RT "The complete amino-acid sequence of the sweet protein thaumatin I.";
RL Eur. J. Biochem. 96:193-204(1979).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 23-229, DISULFIDE BONDS, AND
RP FUNCTION.
RX PubMed=3856268; DOI=10.1073/pnas.82.5.1406;
RA de Vos A.M., Hatada M., van der Wel H., Krabbendam H., Peerdeman A.F.,
RA Kim S.-H.;
RT "Three-dimensional structure of thaumatin I, an intensely sweet protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 82:1406-1409(1985).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 23-229.
RX PubMed=2360997; DOI=10.1080/07391102.1990.10508545;
RA McPherson A., Weickmann J.;
RT "X-ray analysis of new crystal forms of the sweet protein thaumatin.";
RL J. Biomol. Struct. Dyn. 7:1053-1060(1990).
RN [6]
RP X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 23-229.
RX PubMed=1469722; DOI=10.1016/0022-2836(92)90873-i;
RA Ogata C.M., Gordon P.F., de Vos A.M., Kim S.-H.;
RT "Crystal structure of a sweet tasting protein thaumatin I, at 1.65-A
RT resolution.";
RL J. Mol. Biol. 228:893-908(1992).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 23-229, AND DISULFIDE BONDS.
RX PubMed=17327674; DOI=10.1107/s0907444906055624;
RA Mueller-Dieckmann C., Panjikar S., Schmidt A., Mueller S., Kuper J.,
RA Geerlof A., Wilmanns M., Singh R.K., Tucker P.A., Weiss M.S.;
RT "On the routine use of soft X-rays in macromolecular crystallography. Part
RT IV. Efficient determination of anomalous substructures in biomacromolecules
RT using longer X-ray wavelengths.";
RL Acta Crystallogr. D 63:366-380(2007).
RN [8]
RP X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 23-229, AND DISULFIDE BONDS.
RX PubMed=25384243; DOI=10.1038/nmeth.3172;
RA Sugahara M., Mizohata E., Nango E., Suzuki M., Tanaka T., Masuda T.,
RA Tanaka R., Shimamura T., Tanaka Y., Suno C., Ihara K., Pan D.,
RA Kakinouchi K., Sugiyama S., Murata M., Inoue T., Tono K., Song C., Park J.,
RA Kameshima T., Hatsui T., Joti Y., Yabashi M., Iwata S.;
RT "Grease matrix as a versatile carrier of proteins for serial
RT crystallography.";
RL Nat. Methods 12:61-63(2015).
CC -!- FUNCTION: Taste-modifying protein; intensely sweet-tasting. It is
CC 100000 times sweeter than sucrose on a molar basis.
CC {ECO:0000305|PubMed:3856268}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Thaumatin accumulates
CC in vesicle-like organelles. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the thaumatin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00699}.
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DR EMBL; AB265690; BAF44567.1; -; mRNA.
DR EMBL; AF355098; AAL83964.1; -; mRNA.
DR PIR; A03377; QTTC1.
DR PDB; 1LR2; X-ray; 1.80 A; A=23-229.
DR PDB; 1LR3; X-ray; 1.80 A; A=23-229.
DR PDB; 1LXZ; X-ray; 1.25 A; A=23-229.
DR PDB; 1LY0; X-ray; 1.36 A; A=23-229.
DR PDB; 1PP3; X-ray; 1.60 A; A/B=23-229.
DR PDB; 1RQW; X-ray; 1.05 A; A=23-229.
DR PDB; 1THI; X-ray; 3.20 A; A=23-229.
DR PDB; 1THU; X-ray; 2.60 A; A=23-229.
DR PDB; 1THV; X-ray; 1.75 A; A=23-229.
DR PDB; 1THW; X-ray; 1.75 A; A=23-229.
DR PDB; 2A7I; X-ray; 1.75 A; X=23-229.
DR PDB; 2BLR; X-ray; 1.40 A; A=23-228.
DR PDB; 2BLU; X-ray; 1.40 A; A=23-228.
DR PDB; 2D8O; X-ray; 2.38 A; A=23-229.
DR PDB; 2D8P; X-ray; 2.30 A; A=23-229.
DR PDB; 2G4Y; X-ray; 1.98 A; A=23-229.
DR PDB; 2OQN; X-ray; 1.90 A; A=23-229.
DR PDB; 2PE7; X-ray; 1.46 A; A=23-229.
DR PDB; 2VHK; X-ray; 0.94 A; A=23-228.
DR PDB; 2VHR; X-ray; 0.95 A; A=23-229.
DR PDB; 2VI1; X-ray; 1.04 A; A=23-229.
DR PDB; 2VI2; X-ray; 1.08 A; A=23-229.
DR PDB; 2VI3; X-ray; 0.98 A; A=23-229.
DR PDB; 2VI4; X-ray; 1.10 A; A=23-229.
DR PDB; 2VU6; X-ray; 0.95 A; A=23-229.
DR PDB; 2VU7; X-ray; 1.08 A; A=23-229.
DR PDB; 2WBZ; X-ray; 1.60 A; A=23-228.
DR PDB; 3AL7; X-ray; 1.10 A; A=23-229.
DR PDB; 3ALD; X-ray; 1.10 A; A=23-229.
DR PDB; 3DZN; X-ray; 1.51 A; A=23-229.
DR PDB; 3DZP; X-ray; 1.51 A; A=23-229.
DR PDB; 3DZR; X-ray; 1.51 A; A=23-229.
DR PDB; 3E0A; X-ray; 1.51 A; A=23-229.
DR PDB; 3E3S; X-ray; 1.73 A; A=23-229.
DR PDB; 3N02; X-ray; 1.50 A; A=23-228.
DR PDB; 3N03; X-ray; 1.50 A; A=23-228.
DR PDB; 3QY5; X-ray; 1.25 A; A=23-229.
DR PDB; 3V7V; X-ray; 2.30 A; A=23-229.
DR PDB; 3V82; X-ray; 2.30 A; A=23-229.
DR PDB; 3V84; X-ray; 2.30 A; A=23-229.
DR PDB; 3V87; X-ray; 2.30 A; A=23-229.
DR PDB; 3V88; X-ray; 2.30 A; A=23-229.
DR PDB; 3V8A; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCE; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCG; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCH; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCI; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCJ; X-ray; 2.30 A; A=23-229.
DR PDB; 3VCK; X-ray; 2.30 A; A=23-229.
DR PDB; 3VHF; X-ray; 1.39 A; A=23-229.
DR PDB; 3VHG; X-ray; 1.00 A; A=23-229.
DR PDB; 3VJQ; X-ray; 1.00 A; A=23-229.
DR PDB; 3WXS; X-ray; 2.00 A; A=23-229.
DR PDB; 3X3O; X-ray; 1.48 A; A=23-229.
DR PDB; 3X3P; X-ray; 1.48 A; A=23-229.
DR PDB; 3X3Q; X-ray; 1.50 A; A=23-229.
DR PDB; 3X3R; X-ray; 1.52 A; A=23-229.
DR PDB; 3X3S; X-ray; 1.46 A; A=23-229.
DR PDB; 3X3T; X-ray; 1.50 A; A=23-229.
DR PDB; 3ZEJ; X-ray; 1.55 A; A=23-229.
DR PDB; 4AXR; X-ray; 1.38 A; A=23-229.
DR PDB; 4AXU; X-ray; 1.38 A; A=23-228.
DR PDB; 4BAL; X-ray; 1.30 A; A=23-229.
DR PDB; 4BAR; X-ray; 1.20 A; A=23-229.
DR PDB; 4C3C; X-ray; 1.80 A; A=23-229.
DR PDB; 4DC5; X-ray; 1.48 A; A=23-229.
DR PDB; 4DC6; X-ray; 1.48 A; A=23-229.
DR PDB; 4DIY; X-ray; 1.98 A; A=23-229.
DR PDB; 4DIZ; X-ray; 1.98 A; A=23-229.
DR PDB; 4DJ0; X-ray; 1.98 A; A=23-229.
DR PDB; 4DJ1; X-ray; 1.98 A; A=23-229.
DR PDB; 4EK0; X-ray; 1.52 A; A=23-229.
DR PDB; 4EKA; X-ray; 1.55 A; A=23-229.
DR PDB; 4EKB; X-ray; 1.52 A; A=23-229.
DR PDB; 4EKH; X-ray; 1.75 A; A=23-229.
DR PDB; 4EKO; X-ray; 1.52 A; A=23-229.
DR PDB; 4EKT; X-ray; 1.75 A; A=23-229.
DR PDB; 4EL2; X-ray; 1.52 A; A=23-229.
DR PDB; 4EL3; X-ray; 1.95 A; A=23-229.
DR PDB; 4EL7; X-ray; 1.52 A; A=23-229.
DR PDB; 4ELA; X-ray; 2.00 A; A=23-229.
DR PDB; 4TVT; X-ray; 1.20 A; A=23-229.
DR PDB; 4XVB; X-ray; 1.52 A; A=23-229.
DR PDB; 4ZG3; X-ray; 1.20 A; A=23-229.
DR PDB; 4ZXR; X-ray; 1.92 A; A=23-229.
DR PDB; 5A47; X-ray; 1.20 A; A=23-229.
DR PDB; 5AMZ; X-ray; 1.40 A; A=23-228.
DR PDB; 5AVG; X-ray; 0.95 A; A=23-228.
DR PDB; 5FGT; X-ray; 2.10 A; A=23-229.
DR PDB; 5FGX; X-ray; 2.13 A; A=23-229.
DR PDB; 5GQP; X-ray; 1.30 A; A=23-229.
DR PDB; 5JVX; X-ray; 1.70 A; A=23-229.
DR PDB; 5K7Q; EM; 2.50 A; A=23-229.
DR PDB; 5KVW; X-ray; 1.59 A; A=23-229.
DR PDB; 5KVX; X-ray; 1.59 A; A=23-229.
DR PDB; 5KVZ; X-ray; 1.59 A; A=23-229.
DR PDB; 5KW0; X-ray; 1.59 A; A=23-229.
DR PDB; 5KW3; X-ray; 1.55 A; A=23-229.
DR PDB; 5KW4; X-ray; 1.55 A; A=23-229.
DR PDB; 5KW5; X-ray; 1.55 A; A=23-229.
DR PDB; 5KW7; X-ray; 1.55 A; A=23-229.
DR PDB; 5KW8; X-ray; 1.55 A; A=23-229.
DR PDB; 5L4R; X-ray; 1.45 A; A=23-229.
DR PDB; 5LH0; X-ray; 1.88 A; A=23-229.
DR PDB; 5LH1; X-ray; 1.90 A; A=23-229.
DR PDB; 5LH3; X-ray; 1.64 A; A=23-229.
DR PDB; 5LH5; X-ray; 1.69 A; A=23-229.
DR PDB; 5LH6; X-ray; 2.16 A; A=23-229.
DR PDB; 5LH7; X-ray; 2.28 A; A=23-229.
DR PDB; 5LMH; X-ray; 1.96 A; A=23-229.
DR PDB; 5LN0; X-ray; 1.95 A; A=23-229.
DR PDB; 5MJG; X-ray; 2.10 A; A=23-229.
DR PDB; 5SW0; X-ray; 1.27 A; A=23-229.
DR PDB; 5SW1; X-ray; 1.10 A; A=23-229.
DR PDB; 5SW2; X-ray; 1.20 A; A=23-229.
DR PDB; 5T3G; X-ray; 1.55 A; A=23-229.
DR PDB; 5TCL; X-ray; 3.20 A; A=23-229.
DR PDB; 5WR8; X-ray; 1.55 A; A=23-229.
DR PDB; 5X9L; X-ray; 0.90 A; A=23-229.
DR PDB; 5X9M; X-ray; 0.93 A; A=23-229.
DR PDB; 5YYP; X-ray; 1.01 A; A=23-229.
DR PDB; 5YYQ; X-ray; 1.07 A; A=23-229.
DR PDB; 5YYR; X-ray; 1.07 A; A=23-229.
DR PDB; 6C5Y; X-ray; 2.50 A; A=23-229.
DR PDB; 6C6W; X-ray; 2.23 A; A=23-229.
DR PDB; 6COA; X-ray; 1.20 A; A=23-229.
DR PDB; 6E0D; X-ray; 2.24 A; A=1-235.
DR PDB; 6FJ6; X-ray; 1.08 A; A=23-229.
DR PDB; 6FJ8; X-ray; 1.50 A; A=23-229.
DR PDB; 6FJ9; X-ray; 1.50 A; A=23-229.
DR PDB; 6G89; X-ray; 2.36 A; C=23-228.
DR PDB; 6O8A; X-ray; 2.60 A; A=23-229.
DR PDB; 6RVO; X-ray; 1.97 A; A=23-229.
DR PDB; 6S19; X-ray; 2.65 A; A=23-229.
DR PDB; 6S1D; X-ray; 2.65 A; A=23-229.
DR PDB; 6S1E; X-ray; 1.95 A; A=23-229.
DR PDB; 6S1G; X-ray; 2.00 A; A=23-229.
DR PDB; 6SRJ; X-ray; 2.30 A; A=23-229.
DR PDB; 6SRK; X-ray; 2.30 A; A=23-229.
DR PDB; 6SRL; X-ray; 2.30 A; A=23-229.
DR PDB; 6SRO; X-ray; 2.30 A; A=23-229.
DR PDB; 6SRP; X-ray; 2.30 A; A=23-229.
DR PDB; 6SRQ; X-ray; 2.30 A; A=23-229.
DR PDB; 6YBX; X-ray; 1.14 A; A=23-229.
DR PDB; 6YC5; X-ray; 1.35 A; A=23-229.
DR PDB; 6ZHN; EM; 2.76 A; A=23-229.
DR PDB; 7AC3; X-ray; 1.65 A; A=23-229.
DR PDB; 7AT6; X-ray; 1.46 A; A=23-229.
DR PDB; 7LFG; X-ray; 1.22 A; A=23-229.
DR PDB; 7LJV; X-ray; 1.48 A; A=23-229.
DR PDB; 7LJW; X-ray; 1.22 A; A=23-229.
DR PDB; 7LJZ; X-ray; 1.29 A; A=23-229.
DR PDB; 7LK5; X-ray; 1.38 A; A=23-229.
DR PDB; 7LK6; X-ray; 1.48 A; A=23-229.
DR PDB; 7LNB; X-ray; 1.22 A; A=23-229.
DR PDB; 7LNC; X-ray; 1.22 A; A=23-229.
DR PDB; 7LND; X-ray; 1.22 A; A=23-229.
DR PDB; 7O44; X-ray; 2.00 A; A=23-229.
DR PDBsum; 1LR2; -.
DR PDBsum; 1LR3; -.
DR PDBsum; 1LXZ; -.
DR PDBsum; 1LY0; -.
DR PDBsum; 1PP3; -.
DR PDBsum; 1RQW; -.
DR PDBsum; 1THI; -.
DR PDBsum; 1THU; -.
DR PDBsum; 1THV; -.
DR PDBsum; 1THW; -.
DR PDBsum; 2A7I; -.
DR PDBsum; 2BLR; -.
DR PDBsum; 2BLU; -.
DR PDBsum; 2D8O; -.
DR PDBsum; 2D8P; -.
DR PDBsum; 2G4Y; -.
DR PDBsum; 2OQN; -.
DR PDBsum; 2PE7; -.
DR PDBsum; 2VHK; -.
DR PDBsum; 2VHR; -.
DR PDBsum; 2VI1; -.
DR PDBsum; 2VI2; -.
DR PDBsum; 2VI3; -.
DR PDBsum; 2VI4; -.
DR PDBsum; 2VU6; -.
DR PDBsum; 2VU7; -.
DR PDBsum; 2WBZ; -.
DR PDBsum; 3AL7; -.
DR PDBsum; 3ALD; -.
DR PDBsum; 3DZN; -.
DR PDBsum; 3DZP; -.
DR PDBsum; 3DZR; -.
DR PDBsum; 3E0A; -.
DR PDBsum; 3E3S; -.
DR PDBsum; 3N02; -.
DR PDBsum; 3N03; -.
DR PDBsum; 3QY5; -.
DR PDBsum; 3V7V; -.
DR PDBsum; 3V82; -.
DR PDBsum; 3V84; -.
DR PDBsum; 3V87; -.
DR PDBsum; 3V88; -.
DR PDBsum; 3V8A; -.
DR PDBsum; 3VCE; -.
DR PDBsum; 3VCG; -.
DR PDBsum; 3VCH; -.
DR PDBsum; 3VCI; -.
DR PDBsum; 3VCJ; -.
DR PDBsum; 3VCK; -.
DR PDBsum; 3VHF; -.
DR PDBsum; 3VHG; -.
DR PDBsum; 3VJQ; -.
DR PDBsum; 3WXS; -.
DR PDBsum; 3X3O; -.
DR PDBsum; 3X3P; -.
DR PDBsum; 3X3Q; -.
DR PDBsum; 3X3R; -.
DR PDBsum; 3X3S; -.
DR PDBsum; 3X3T; -.
DR PDBsum; 3ZEJ; -.
DR PDBsum; 4AXR; -.
DR PDBsum; 4AXU; -.
DR PDBsum; 4BAL; -.
DR PDBsum; 4BAR; -.
DR PDBsum; 4C3C; -.
DR PDBsum; 4DC5; -.
DR PDBsum; 4DC6; -.
DR PDBsum; 4DIY; -.
DR PDBsum; 4DIZ; -.
DR PDBsum; 4DJ0; -.
DR PDBsum; 4DJ1; -.
DR PDBsum; 4EK0; -.
DR PDBsum; 4EKA; -.
DR PDBsum; 4EKB; -.
DR PDBsum; 4EKH; -.
DR PDBsum; 4EKO; -.
DR PDBsum; 4EKT; -.
DR PDBsum; 4EL2; -.
DR PDBsum; 4EL3; -.
DR PDBsum; 4EL7; -.
DR PDBsum; 4ELA; -.
DR PDBsum; 4TVT; -.
DR PDBsum; 4XVB; -.
DR PDBsum; 4ZG3; -.
DR PDBsum; 4ZXR; -.
DR PDBsum; 5A47; -.
DR PDBsum; 5AMZ; -.
DR PDBsum; 5AVG; -.
DR PDBsum; 5FGT; -.
DR PDBsum; 5FGX; -.
DR PDBsum; 5GQP; -.
DR PDBsum; 5JVX; -.
DR PDBsum; 5K7Q; -.
DR PDBsum; 5KVW; -.
DR PDBsum; 5KVX; -.
DR PDBsum; 5KVZ; -.
DR PDBsum; 5KW0; -.
DR PDBsum; 5KW3; -.
DR PDBsum; 5KW4; -.
DR PDBsum; 5KW5; -.
DR PDBsum; 5KW7; -.
DR PDBsum; 5KW8; -.
DR PDBsum; 5L4R; -.
DR PDBsum; 5LH0; -.
DR PDBsum; 5LH1; -.
DR PDBsum; 5LH3; -.
DR PDBsum; 5LH5; -.
DR PDBsum; 5LH6; -.
DR PDBsum; 5LH7; -.
DR PDBsum; 5LMH; -.
DR PDBsum; 5LN0; -.
DR PDBsum; 5MJG; -.
DR PDBsum; 5SW0; -.
DR PDBsum; 5SW1; -.
DR PDBsum; 5SW2; -.
DR PDBsum; 5T3G; -.
DR PDBsum; 5TCL; -.
DR PDBsum; 5WR8; -.
DR PDBsum; 5X9L; -.
DR PDBsum; 5X9M; -.
DR PDBsum; 5YYP; -.
DR PDBsum; 5YYQ; -.
DR PDBsum; 5YYR; -.
DR PDBsum; 6C5Y; -.
DR PDBsum; 6C6W; -.
DR PDBsum; 6COA; -.
DR PDBsum; 6E0D; -.
DR PDBsum; 6FJ6; -.
DR PDBsum; 6FJ8; -.
DR PDBsum; 6FJ9; -.
DR PDBsum; 6G89; -.
DR PDBsum; 6O8A; -.
DR PDBsum; 6RVO; -.
DR PDBsum; 6S19; -.
DR PDBsum; 6S1D; -.
DR PDBsum; 6S1E; -.
DR PDBsum; 6S1G; -.
DR PDBsum; 6SRJ; -.
DR PDBsum; 6SRK; -.
DR PDBsum; 6SRL; -.
DR PDBsum; 6SRO; -.
DR PDBsum; 6SRP; -.
DR PDBsum; 6SRQ; -.
DR PDBsum; 6YBX; -.
DR PDBsum; 6YC5; -.
DR PDBsum; 6ZHN; -.
DR PDBsum; 7AC3; -.
DR PDBsum; 7AT6; -.
DR PDBsum; 7LFG; -.
DR PDBsum; 7LJV; -.
DR PDBsum; 7LJW; -.
DR PDBsum; 7LJZ; -.
DR PDBsum; 7LK5; -.
DR PDBsum; 7LK6; -.
DR PDBsum; 7LNB; -.
DR PDBsum; 7LNC; -.
DR PDBsum; 7LND; -.
DR PDBsum; 7O44; -.
DR AlphaFoldDB; P02883; -.
DR PCDDB; P02883; -.
DR SMR; P02883; -.
DR Allergome; 9233; Tha da TLP.
DR EvolutionaryTrace; P02883; -.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR Gene3D; 2.60.110.10; -; 1.
DR InterPro; IPR037176; Osmotin/thaumatin-like_sf.
DR InterPro; IPR001938; Thaumatin.
DR InterPro; IPR017949; Thaumatin_CS.
DR PANTHER; PTHR31048; PTHR31048; 1.
DR Pfam; PF00314; Thaumatin; 1.
DR PIRSF; PIRSF002703; Thaumatin; 1.
DR PRINTS; PR00347; THAUMATIN.
DR SMART; SM00205; THN; 1.
DR SUPFAM; SSF49870; SSF49870; 1.
DR PROSITE; PS00316; THAUMATIN_1; 1.
DR PROSITE; PS51367; THAUMATIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasmic vesicle; Direct protein sequencing;
KW Disulfide bond; Signal; Taste-modifying protein.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:456365"
FT CHAIN 23..229
FT /note="Thaumatin I"
FT /evidence="ECO:0000269|PubMed:456365"
FT /id="PRO_0000096221"
FT PROPEP 230..235
FT /note="Removed in mature form"
FT /evidence="ECO:0000269|PubMed:456365"
FT /id="PRO_0000443721"
FT DISULFID 31..226
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 78..88
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 93..99
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 143..215
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 148..199
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 156..167
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 171..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT DISULFID 181..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00699,
FT ECO:0000269|PubMed:17327674, ECO:0000269|PubMed:25384243,
FT ECO:0000269|PubMed:3856268, ECO:0007744|PDB:2G4Y,
FT ECO:0007744|PDB:3WXS"
FT STRAND 24..29
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 31..33
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 35..40
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 42..53
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 69..77
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 84..87
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 89..91
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 96..98
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 109..116
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 119..125
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 130..132
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 134..143
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 146..148
FT /evidence="ECO:0007829|PDB:5X9L"
FT HELIX 152..155
FT /evidence="ECO:0007829|PDB:5X9L"
FT HELIX 158..160
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 165..167
FT /evidence="ECO:0007829|PDB:5X9L"
FT HELIX 170..174
FT /evidence="ECO:0007829|PDB:5X9L"
FT HELIX 177..180
FT /evidence="ECO:0007829|PDB:5X9L"
FT TURN 181..183
FT /evidence="ECO:0007829|PDB:5X9L"
FT HELIX 190..198
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 202..205
FT /evidence="ECO:0007829|PDB:2D8O"
FT STRAND 213..216
FT /evidence="ECO:0007829|PDB:5X9L"
FT STRAND 221..227
FT /evidence="ECO:0007829|PDB:5X9L"
SQ SEQUENCE 235 AA; 25440 MW; 9E1A62D6B1EE8FEF CRC64;
MAATTCFFFL FPFLLLLTLS RAATFEIVNR CSYTVWAAAS KGDAALDAGG RQLNSGESWT
INVEPGTNGG KIWARTDCYF DDSGSGICKT GDCGGLLRCK RFGRPPTTLA EFSLNQYGKD
YIDISNIKGF NVPMDFSPTT RGCRGVRCAA DIVGQCPAKL KAPGGGCNDA CTVFQTSEYC
CTTGKCGPTE YSRFFKRLCP DAFSYVLDKP TTVTCPGSSN YRVTFCPTAL ELEDE
