ID   THMAC_HIRME             Reviewed;          75 AA.
AC   A8I0L8; A8IK85;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   25-MAY-2022, entry version 27.
DE   RecName: Full=Theromacin;
OS   Hirudo medicinalis (Medicinal leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Hirudinida; Hirudiniformes; Hirudinidae; Hirudo.
OX   NCBI_TaxID=6421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schikorski D., Salzet M., Tasiemski A.;
RT   "Antimicrobial peptides isolated from the medicinal leech.";
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has a bactericial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the macin family. {ECO:0000305}.
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DR   EMBL; EU164975; ABV56207.1; -; mRNA.
DR   EMBL; EU149766; ABV56569.1; -; mRNA.
DR   PDB; 2LN8; NMR; -; A=1-75.
DR   PDBsum; 2LN8; -.
DR   AlphaFoldDB; A8I0L8; -.
DR   BMRB; A8I0L8; -.
DR   SMR; A8I0L8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   Gene3D; 3.30.30.100; -; 1.
DR   InterPro; IPR029230; Macin.
DR   InterPro; IPR038456; Macin_sf.
DR   Pfam; PF14865; Macin; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antimicrobial; Disulfide bond; Secreted.
FT   CHAIN           1..75
FT                   /note="Theromacin"
FT                   /id="PRO_0000342178"
FT   DISULFID        2..9
FT                   /evidence="ECO:0000250"
FT   DISULFID        24..28
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..47
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..59
FT                   /evidence="ECO:0000250"
FT   HELIX           3..6
FT                   /evidence="ECO:0007829|PDB:2LN8"
FT   TURN            18..21
FT                   /evidence="ECO:0007829|PDB:2LN8"
FT   HELIX           25..30
FT                   /evidence="ECO:0007829|PDB:2LN8"
FT   STRAND          35..39
FT                   /evidence="ECO:0007829|PDB:2LN8"
FT   STRAND          57..60
FT                   /evidence="ECO:0007829|PDB:2LN8"
FT   HELIX           71..73
FT                   /evidence="ECO:0007829|PDB:2LN8"
SQ   SEQUENCE   75 AA;  8453 MW;  B3D71CB5430DE3D8 CRC64;
     GCFEDWSRCS PSTASATGVL WRSCDSYCKV CFKADRGECY DSPSLNCPHR LPNNKQCRCI
     NARTAKDNRN PTCWA