THMS2_HUMAN
ID THMS2_HUMAN Reviewed; 643 AA.
AC Q5TEJ8; A2RTZ3; B4DZT9; B4DZY3; O60560; Q5TEJ1; Q5TEJ9; Q5TEK1; Q68DP4;
AC Q9BYB6; Q9NS90;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Protein THEMIS2 {ECO:0000305};
DE AltName: Full=Induced by contact to basement membrane 1 protein {ECO:0000303|PubMed:20644716};
DE Short=Protein ICB-1;
DE AltName: Full=Thymocyte-expressed molecule involved in selection protein 2;
GN Name=THEMIS2 {ECO:0000312|HGNC:HGNC:16839};
GN Synonyms=C1orf38, ICB1 {ECO:0000303|PubMed:20644716};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 4-643 (ISOFORM 5), AND VARIANT GLU-511.
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 112-643 (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Endometrial adenocarcinoma;
RX PubMed=9563507; DOI=10.1016/s0014-5793(98)00278-6;
RA Treeck O., Strunck E., Vollmer G.;
RT "A novel basement membrane-induced gene identified in the human endometrial
RT adenocarcinoma cell line HEC1B.";
RL FEBS Lett. 425:426-430(1998).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 112-643 (ISOFORM 3), NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 143-643 (ISOFORM 2), AND VARIANT GLU-511.
RC TISSUE=Leukocyte;
RA Tanaka K., Imai H., Odani T., Tachibana M., Fujita S.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION.
RX PubMed=20644716; DOI=10.1371/journal.pone.0011465;
RA Peirce M.J., Brook M., Morrice N., Snelgrove R., Begum S., Lanfrancotti A.,
RA Notley C., Hussell T., Cope A.P., Wait R.;
RT "Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage
RT Toll-like receptor signaling and cytokine production.";
RL PLoS ONE 5:E11465-E11465(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-593, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May constitute a control point in macrophage inflammatory
CC response, promoting LPS-induced TLR4-mediated TNF production
CC (PubMed:20644716). Determines the threshold for activation of B cells
CC by low-affinity and low-avidity ligands via PLCG2 activation and its
CC downstream pathways (By similarity). {ECO:0000250|UniProtKB:Q91YX0,
CC ECO:0000269|PubMed:20644716}.
CC -!- SUBUNIT: Interacts with VAV1. Interacts with LAT. Interacts
CC constitutively with GRB2, LYN and PLCG2; these interactions increase
CC the activation of PLCG2 and its downstream pathways following B cell
CC receptor stimulation. {ECO:0000250|UniProtKB:Q91YX0}.
CC -!- INTERACTION:
CC Q5TEJ8; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-2806032, EBI-945833;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91YX0}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q91YX0}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q5TEJ8-1; Sequence=Displayed;
CC Name=2; Synonyms=ICB1-beta;
CC IsoId=Q5TEJ8-2; Sequence=VSP_015326, VSP_015327;
CC Name=3; Synonyms=ICB1-gamma;
CC IsoId=Q5TEJ8-3; Sequence=VSP_015330;
CC Name=4;
CC IsoId=Q5TEJ8-4; Sequence=VSP_015328, VSP_015329;
CC Name=5;
CC IsoId=Q5TEJ8-5; Sequence=VSP_037967;
CC Name=6;
CC IsoId=Q5TEJ8-6; Sequence=VSP_037966;
CC -!- TISSUE SPECIFICITY: Expressed in different endometrial adenocarcinoma
CC cell lines and various other cell lines apart from the prostate cell
CC line LNCaP and the ovarian cancer cell line BG1.
CC {ECO:0000269|PubMed:9563507}.
CC -!- INDUCTION: By contact to a reconstituted basement membrane.
CC -!- PTM: Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by
CC Src kinases (Lck or Fyn) following BCR engagement.
CC {ECO:0000250|UniProtKB:Q91YX0}.
CC -!- SIMILARITY: Belongs to the themis family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC16284.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA96464.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB33313.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAG64201.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAI21769.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI21771.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI21773.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CR749321; CAH18176.1; -; mRNA.
DR EMBL; AK303090; BAG64201.1; ALT_INIT; mRNA.
DR EMBL; AK303141; BAG64245.1; -; mRNA.
DR EMBL; AL109927; CAI21769.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL109927; CAI21770.1; -; Genomic_DNA.
DR EMBL; AL109927; CAI21771.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL109927; CAI21772.1; -; Genomic_DNA.
DR EMBL; AL109927; CAI21773.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC031655; AAH31655.2; -; mRNA.
DR EMBL; BC132692; AAI32693.1; -; mRNA.
DR EMBL; BC133049; AAI33050.1; -; mRNA.
DR EMBL; AF044895; AAC16284.1; ALT_FRAME; mRNA.
DR EMBL; AB050854; BAB33313.1; ALT_INIT; mRNA.
DR EMBL; AB035482; BAA96464.1; ALT_INIT; mRNA.
DR CCDS; CCDS30653.1; -. [Q5TEJ8-2]
DR CCDS; CCDS30654.1; -. [Q5TEJ8-4]
DR CCDS; CCDS41290.1; -. [Q5TEJ8-1]
DR CCDS; CCDS65461.1; -. [Q5TEJ8-5]
DR RefSeq; NP_001034566.1; NM_001039477.2. [Q5TEJ8-4]
DR RefSeq; NP_001099026.1; NM_001105556.2. [Q5TEJ8-1]
DR RefSeq; NP_001273042.1; NM_001286113.1. [Q5TEJ8-5]
DR RefSeq; NP_001273044.1; NM_001286115.1. [Q5TEJ8-6]
DR RefSeq; NP_004839.2; NM_004848.3. [Q5TEJ8-2]
DR RefSeq; XP_006711113.1; XM_006711050.1. [Q5TEJ8-3]
DR AlphaFoldDB; Q5TEJ8; -.
DR BioGRID; 114858; 3.
DR IntAct; Q5TEJ8; 5.
DR STRING; 9606.ENSP00000363031; -.
DR iPTMnet; Q5TEJ8; -.
DR PhosphoSitePlus; Q5TEJ8; -.
DR BioMuta; THEMIS2; -.
DR DMDM; 73920021; -.
DR EPD; Q5TEJ8; -.
DR jPOST; Q5TEJ8; -.
DR MassIVE; Q5TEJ8; -.
DR MaxQB; Q5TEJ8; -.
DR PaxDb; Q5TEJ8; -.
DR PeptideAtlas; Q5TEJ8; -.
DR PRIDE; Q5TEJ8; -.
DR ProteomicsDB; 65054; -. [Q5TEJ8-1]
DR ProteomicsDB; 65055; -. [Q5TEJ8-2]
DR ProteomicsDB; 65056; -. [Q5TEJ8-3]
DR ProteomicsDB; 65057; -. [Q5TEJ8-4]
DR ProteomicsDB; 65058; -. [Q5TEJ8-5]
DR ProteomicsDB; 65059; -. [Q5TEJ8-6]
DR Antibodypedia; 30867; 107 antibodies from 21 providers.
DR DNASU; 9473; -.
DR Ensembl; ENST00000328928.11; ENSP00000329862.7; ENSG00000130775.16. [Q5TEJ8-5]
DR Ensembl; ENST00000373921.8; ENSP00000363031.3; ENSG00000130775.16. [Q5TEJ8-1]
DR Ensembl; ENST00000373925.5; ENSP00000363035.1; ENSG00000130775.16. [Q5TEJ8-2]
DR Ensembl; ENST00000373927.7; ENSP00000363037.3; ENSG00000130775.16. [Q5TEJ8-4]
DR GeneID; 9473; -.
DR KEGG; hsa:9473; -.
DR MANE-Select; ENST00000373921.8; ENSP00000363031.3; NM_001105556.3; NP_001099026.1.
DR UCSC; uc001boz.5; human. [Q5TEJ8-1]
DR CTD; 9473; -.
DR DisGeNET; 9473; -.
DR GeneCards; THEMIS2; -.
DR HGNC; HGNC:16839; THEMIS2.
DR HPA; ENSG00000130775; Tissue enhanced (bone marrow, lymphoid tissue).
DR MIM; 617856; gene.
DR neXtProt; NX_Q5TEJ8; -.
DR OpenTargets; ENSG00000130775; -.
DR PharmGKB; PA128394550; -.
DR VEuPathDB; HostDB:ENSG00000130775; -.
DR eggNOG; ENOG502QSJR; Eukaryota.
DR GeneTree; ENSGT00530000063770; -.
DR HOGENOM; CLU_1069427_0_0_1; -.
DR InParanoid; Q5TEJ8; -.
DR OMA; DASHPAD; -.
DR OrthoDB; 337909at2759; -.
DR PhylomeDB; Q5TEJ8; -.
DR TreeFam; TF333479; -.
DR PathwayCommons; Q5TEJ8; -.
DR SignaLink; Q5TEJ8; -.
DR BioGRID-ORCS; 9473; 17 hits in 1079 CRISPR screens.
DR ChiTaRS; THEMIS2; human.
DR GenomeRNAi; 9473; -.
DR Pharos; Q5TEJ8; Tbio.
DR PRO; PR:Q5TEJ8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TEJ8; protein.
DR Bgee; ENSG00000130775; Expressed in monocyte and 158 other tissues.
DR ExpressionAtlas; Q5TEJ8; baseline and differential.
DR Genevisible; Q5TEJ8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0050864; P:regulation of B cell activation; ISS:UniProtKB.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR025946; CABIT_dom.
DR InterPro; IPR039671; THEMIS.
DR PANTHER; PTHR15215; PTHR15215; 1.
DR Pfam; PF12736; CABIT; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Immunity; Inflammatory response; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..643
FT /note="Protein THEMIS2"
FT /id="PRO_0000084143"
FT REGION 1..238
FT /note="CABIT 1"
FT REGION 239..514
FT /note="CABIT 2"
FT REGION 546..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 593
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 632
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q91YX0"
FT VAR_SEQ 79..123
FT /note="GYFTPLNTPQSYETLEELVSATTQSSKQLPTCFMSTHRIVTEGRV -> VFS
FT SLRIAATRSAAQTQGEDLARVHQGWLQYVQQDSCPQEGPQAR (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_015328"
FT VAR_SEQ 124..643
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_015329"
FT VAR_SEQ 186..381
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037966"
FT VAR_SEQ 216..260
FT /note="MRRTIVKIPSTLEVDVEDVTASSRHVHFIKPLLLSEVLAWEGPFP -> IFS
FT SLRIAATRSAAQTQGEDLARVHQGWLQYVQQDSCPQEGPQAR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_015326"
FT VAR_SEQ 252..396
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.6"
FT /id="VSP_015330"
FT VAR_SEQ 261..643
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.6"
FT /id="VSP_015327"
FT VAR_SEQ 268..396
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037967"
FT VARIANT 431
FT /note="V -> L (in dbSNP:rs35995543)"
FT /id="VAR_051060"
FT VARIANT 511
FT /note="K -> E (in dbSNP:rs3766400)"
FT /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|Ref.6"
FT /id="VAR_051061"
FT CONFLICT 451
FT /note="L -> M (in Ref. 6; AAC16284)"
FT /evidence="ECO:0000305"
FT CONFLICT 466
FT /note="T -> N (in Ref. 6; AAC16284)"
FT /evidence="ECO:0000305"
FT CONFLICT 504
FT /note="W -> R (in Ref. 6; AAC16284)"
FT /evidence="ECO:0000305"
FT CONFLICT 538
FT /note="R -> C (in Ref. 6; AAC16284)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="A -> V (in Ref. 6; AAC16284)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 643 AA; 72049 MW; 1D5FA24F88D2F8EA CRC64;
MEPVPLQDFV RALDPASLPR VLRVCSGVYF EGSIYEISGN ECCLSTGDLI KVTQVRLQKV
VCENPKTSQT MELAPNFQGY FTPLNTPQSY ETLEELVSAT TQSSKQLPTC FMSTHRIVTE
GRVVTEDQLL MLEAVVMHLG IRSARCVLGM EGQQVILHLP LSQKGPFWTW EPSAPRTLLQ
VLQDPALKDL VLTCPTLPWH SLILRPQYEI QAIMHMRRTI VKIPSTLEVD VEDVTASSRH
VHFIKPLLLS EVLAWEGPFP LSMEILEVPE GRPIFLSPWV GSLQKGQRLC VYGLASPPWR
VLASSKGRKV PRHFLVSGGY QGKLRRRPRE FPTAYDLLGA FQPGRPLRVV ATKDCEGERE
ENPEFTSLAV GDRLEVLGPG QAHGAQGSDV DVLVCQRLSD QAGEDEEEEC KEEAESPERV
LLPFHFPGSF VEEMSDSRRY SLADLTAQFS LPCEVKVVAK DTSHPTDPLT SFLGLRLEEK
ITEPFLVVSL DSEPGMCFEI PPRWLDLTVV KAKGQPDLPE GSLPIATVEE LTDTFYYRLR
KLPACEIQAP PPRPPKNQGL SKQRRHSSEG GVKSSQVLGL QQHARLPKPK AKTLPEFIKD
GSSTYSKIPA HRKGHRPAKP QRQDLDDDEH DYEEILEQFQ KTI
