THMS3_MOUSE
ID THMS3_MOUSE Reviewed; 569 AA.
AC Q9CU24;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Protein THEMIS3;
DE AltName: Full=Thymocyte-expressed molecule involved in selection protein 3;
GN Name=Themis3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cecum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=19597499; DOI=10.1038/ni.1766;
RA Fu G., Vallee S., Rybakin V., McGuire M.V., Ampudia J., Brockmeyer C.,
RA Salek M., Fallen P.R., Hoerter J.A.H., Munshi A., Huang Y.H., Hu J.,
RA Fox H.S., Sauer K., Acuto O., Gascoigne N.R.J.;
RT "Themis controls thymocyte selection through regulation of T cell antigen
RT receptor-mediated signaling.";
RL Nat. Immunol. 10:848-856(2009).
RN [5]
RP IDENTIFICATION.
RX PubMed=19597497; DOI=10.1038/ni.1769;
RA Johnson A.L., Aravind L., Shulzhenko N., Morgun A., Choi S.-Y.,
RA Crockford T.L., Lambe T., Domaschenz H., Kucharska E.M., Zheng L.,
RA Vinuesa C.G., Lenardo M.J., Goodnow C.C., Cornall R.J., Schwartz R.H.;
RT "Themis is a member of a new metazoan gene family and is required for the
RT completion of thymocyte positive selection.";
RL Nat. Immunol. 10:831-839(2009).
CC -!- TISSUE SPECIFICITY: Specifically expressed in the intestine.
CC {ECO:0000269|PubMed:19597499}.
CC -!- SIMILARITY: Belongs to the themis family. {ECO:0000305}.
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DR EMBL; AK018663; BAB31332.1; -; mRNA.
DR EMBL; CH466537; EDL38333.1; -; Genomic_DNA.
DR EMBL; AC122445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT010496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50170.1; -.
DR RefSeq; NP_083274.1; NM_028998.1.
DR AlphaFoldDB; Q9CU24; -.
DR STRING; 10090.ENSMUSP00000024914; -.
DR iPTMnet; Q9CU24; -.
DR PhosphoSitePlus; Q9CU24; -.
DR PaxDb; Q9CU24; -.
DR PRIDE; Q9CU24; -.
DR ProteomicsDB; 262917; -.
DR Ensembl; ENSMUST00000024914; ENSMUSP00000024914; ENSMUSG00000024105.
DR GeneID; 74556; -.
DR KEGG; mmu:74556; -.
DR UCSC; uc008djz.2; mouse.
DR CTD; 74556; -.
DR MGI; MGI:1921806; Themis3.
DR VEuPathDB; HostDB:ENSMUSG00000024105; -.
DR eggNOG; ENOG502SJ9V; Eukaryota.
DR GeneTree; ENSGT00530000063770; -.
DR HOGENOM; CLU_022319_1_0_1; -.
DR InParanoid; Q9CU24; -.
DR OMA; LPCHIRV; -.
DR OrthoDB; 416700at2759; -.
DR PhylomeDB; Q9CU24; -.
DR TreeFam; TF333479; -.
DR BioGRID-ORCS; 74556; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Themis3; mouse.
DR PRO; PR:Q9CU24; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CU24; protein.
DR Bgee; ENSMUSG00000024105; Expressed in jejunum and 34 other tissues.
DR Genevisible; Q9CU24; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR025946; CABIT_dom.
DR InterPro; IPR039671; THEMIS.
DR PANTHER; PTHR15215; PTHR15215; 1.
DR Pfam; PF12736; CABIT; 2.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..569
FT /note="Protein THEMIS3"
FT /id="PRO_0000383152"
FT REGION 1..254
FT /note="CABIT 1"
FT REGION 255..523
FT /note="CABIT 2"
SQ SEQUENCE 569 AA; 64720 MW; 43E910F87E97AD5B CRC64;
MEQTWDSYIS SLNQNSLPRQ VEVTQGRYSG SLENLSFSKG DIITVVDLEP VFVRAELKDG
DQVLDVVTIP LRYEGNFQLM ADPVSFETVA DLTRSVRLPQ SPVAPRSPPR FQNSIPISAD
NLPMKLRKGE TLSLIGFQES RGRRLLQCKV LRKKPPLTVL LPMDCRGHFL ECQDDRFYSI
DTIVRWKMLA GRKRTVRVQA RHHPKLLGPL VPEHFRGHLV LYPCFSVTAN LLGETRVSIP
SDLDISVTEI ARLDRKPRTT MRQIYSMEES KFPVRVKIMN VVQSESKEYP KPLKRGQLLT
ILKTEEVKKF VASEISQGKK GKCFLVPYTY QGLVLRRGRY FYAVSDVAAA MKHGELCFQA
SQDYTSYLGS FASFRANECF LALKKSVVSA EIHGELHRVE VLKCLNIATK AHVKLPLFAV
GKFLELFDGA RPGTLQELCQ VTRLPCHVRV TSPDPSMTVD PLYGTKELRI ENVIIEQCLI
AKDEPTLEDI ISSADMYREW PETTFEIPIE KISCEVLVVE ERSWIADVRK ERCRPLQSIQ
EVTKESLAFS NCLVIRRPPP PVPKPRSLF
