ID   THMYZ_THETS             Reviewed;         107 AA.
AC   Q6T6C1;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Theromyzin;
DE   Flags: Precursor;
OS   Theromyzon tessulatum (Duck leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Theromyzon.
OX   NCBI_TaxID=13286;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-51, SUBCELLULAR
RP   LOCATION, FUNCTION, INDUCTION, AND MASS SPECTROMETRY.
RX   PubMed=15102860; DOI=10.1074/jbc.m312156200;
RA   Tasiemski A., Vandenbulcke F., Mitta G., Lemoine J., Lefebvre C.,
RA   Sautiere P.-E., Salzet M.;
RT   "Molecular characterization of two novel antibacterial peptides inducible
RT   upon bacterial challenge in an annelid, the leech Theromyzon tessulatum.";
RL   J. Biol. Chem. 279:30973-30982(2004).
CC   -!- FUNCTION: Has bacteriostatic activity against M.luteus. No activity
CC       toward E.coli and F.oxysporum. {ECO:0000269|PubMed:15102860}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15102860}.
CC   -!- TISSUE SPECIFICITY: Coelomic liquid (at protein level). Expressed in
CC       large fat cells in contact with coelomic cavities, in intestinal
CC       epithelia and at the epidermis level.
CC   -!- INDUCTION: After blood meal ingestion and upon bacterial challenge.
CC       {ECO:0000269|PubMed:15102860}.
CC   -!- MASS SPECTROMETRY: Mass=9973.1; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:15102860};
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DR   EMBL; AY434033; AAR12066.1; -; mRNA.
DR   AlphaFoldDB; Q6T6C1; -.
DR   SMR; Q6T6C1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:15102860"
FT   CHAIN           22..107
FT                   /note="Theromyzin"
FT                   /id="PRO_0000342177"
SQ   SEQUENCE   107 AA;  12221 MW;  A8EA341F84BD6C41 CRC64;
     MHAKIILALF LGMTAFLAVQ ADHHHDHGHD DHEHEELTLE KIKEKIKDYA DKTPVDQLTE
     RVQAGRDYLL GKGARPSHLP ARVDRHLSKL TAAEKQELAD YLLTFLH