THN24_ARATH
ID THN24_ARATH Reviewed; 134 AA.
AC Q9C8D6;
DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable thionin-2.4;
DE Contains:
DE RecName: Full=Probable thionin-2.4;
DE Contains:
DE RecName: Full=Acidic protein;
DE Flags: Precursor;
GN OrderedLocusNames=At1g66100; ORFNames=F15E12.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC cells. They seem to exert their toxic effect at the level of the cell
CC membrane. Their precise function is not known.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC {ECO:0000305}.
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DR EMBL; AC026480; AAG51299.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34462.1; -; Genomic_DNA.
DR EMBL; AF380652; AAK55733.1; -; mRNA.
DR EMBL; AY054154; AAL06815.1; -; mRNA.
DR PIR; F96685; F96685.
DR RefSeq; NP_176784.1; NM_105281.3.
DR AlphaFoldDB; Q9C8D6; -.
DR SMR; Q9C8D6; -.
DR STRING; 3702.AT1G66100.1; -.
DR PaxDb; Q9C8D6; -.
DR PRIDE; Q9C8D6; -.
DR ProteomicsDB; 246461; -.
DR EnsemblPlants; AT1G66100.1; AT1G66100.1; AT1G66100.
DR GeneID; 842924; -.
DR Gramene; AT1G66100.1; AT1G66100.1; AT1G66100.
DR KEGG; ath:AT1G66100; -.
DR Araport; AT1G66100; -.
DR TAIR; locus:2013835; AT1G66100.
DR eggNOG; ENOG502SUEZ; Eukaryota.
DR HOGENOM; CLU_132328_0_0_1; -.
DR InParanoid; Q9C8D6; -.
DR OMA; DANICCP; -.
DR OrthoDB; 1491167at2759; -.
DR PhylomeDB; Q9C8D6; -.
DR PRO; PR:Q9C8D6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8D6; baseline and differential.
DR Genevisible; Q9C8D6; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; ISS:TAIR.
DR Gene3D; 3.30.1350.10; -; 1.
DR InterPro; IPR001010; Thionin.
DR InterPro; IPR036391; Thionin-like_sf.
DR PANTHER; PTHR33920; PTHR33920; 1.
DR Pfam; PF00321; Thionin; 1.
DR PRINTS; PR00287; THIONIN.
DR SUPFAM; SSF57429; SSF57429; 1.
DR PROSITE; PS00271; THIONIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Plant defense; Reference proteome; Secreted; Signal; Toxin.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..70
FT /note="Probable thionin-2.4"
FT /id="PRO_0000034145"
FT CHAIN 71..134
FT /note="Acidic protein"
FT /id="PRO_0000034146"
FT DISULFID 27..64
FT /evidence="ECO:0000250"
FT DISULFID 28..56
FT /evidence="ECO:0000250"
FT DISULFID 40..50
FT /evidence="ECO:0000250"
SQ SEQUENCE 134 AA; 14147 MW; FCD28EDCB55F30AC CRC64;
MEGKTLIVSV LIMSLFMAQN QVDANICCPS IQARTFYNAC LFAVGSPSSC IRNSSCLDIS
ESTCPRGYTN DILENTGDAV TEYCKLGCVS SVCGALTILQ NSDASEIVNG EVEKCTMACS
TVCTKGSMNA VENA
