ID   THN5_WHEAT              Reviewed;         131 AA.
AC   Q05806;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Type-5 thionin;
DE   Contains:
DE     RecName: Full=Type-5 thionin;
DE     AltName: Full=Type V thionin;
DE   Contains:
DE     RecName: Full=Acidic protein;
DE   Flags: Precursor;
GN   Name=TTHV;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=cv. Chinese Spring; TISSUE=Endosperm;
RX   PubMed=1569564; DOI=10.1016/0022-2836(92)90465-v;
RA   Castagnaro A., Marana C., Carbonero P., Garcia-Olmedo F.;
RT   "Extreme divergence of a novel wheat thionin generated by a mutational
RT   burst specifically affecting the mature protein domain of the precursor.";
RL   J. Mol. Biol. 224:1003-1009(1992).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Developing endosperm.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   EMBL; X61670; CAA43844.1; -; mRNA.
DR   EMBL; X61671; CAA43845.1; -; Genomic_DNA.
DR   PIR; S23511; S23511.
DR   AlphaFoldDB; Q05806; -.
DR   PRIDE; Q05806; -.
DR   EnsemblPlants; TraesCAD_scaffold_059422_01G000600.1; TraesCAD_scaffold_059422_01G000600.1; TraesCAD_scaffold_059422_01G000600.
DR   EnsemblPlants; TraesCLE_scaffold_055580_01G000700.1; TraesCLE_scaffold_055580_01G000700.1; TraesCLE_scaffold_055580_01G000700.
DR   EnsemblPlants; TraesCS1D02G405600.1; TraesCS1D02G405600.1; TraesCS1D02G405600.
DR   EnsemblPlants; TraesPAR_scaffold_055909_01G000100.1; TraesPAR_scaffold_055909_01G000100.1; TraesPAR_scaffold_055909_01G000100.
DR   EnsemblPlants; TraesROB_scaffold_057461_01G000700.1; TraesROB_scaffold_057461_01G000700.1; TraesROB_scaffold_057461_01G000700.
DR   EnsemblPlants; TraesWEE_scaffold_055449_01G000100.1; TraesWEE_scaffold_055449_01G000100.1; TraesWEE_scaffold_055449_01G000100.
DR   Gramene; TraesCAD_scaffold_059422_01G000600.1; TraesCAD_scaffold_059422_01G000600.1; TraesCAD_scaffold_059422_01G000600.
DR   Gramene; TraesCLE_scaffold_055580_01G000700.1; TraesCLE_scaffold_055580_01G000700.1; TraesCLE_scaffold_055580_01G000700.
DR   Gramene; TraesCS1D02G405600.1; TraesCS1D02G405600.1; TraesCS1D02G405600.
DR   Gramene; TraesPAR_scaffold_055909_01G000100.1; TraesPAR_scaffold_055909_01G000100.1; TraesPAR_scaffold_055909_01G000100.
DR   Gramene; TraesROB_scaffold_057461_01G000700.1; TraesROB_scaffold_057461_01G000700.1; TraesROB_scaffold_057461_01G000700.
DR   Gramene; TraesWEE_scaffold_055449_01G000100.1; TraesWEE_scaffold_055449_01G000100.1; TraesWEE_scaffold_055449_01G000100.
DR   HOGENOM; CLU_132328_0_0_1; -.
DR   OMA; PECASRC; -.
DR   Proteomes; UP000019116; Unplaced.
DR   Genevisible; Q05806; TA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR001010; Thionin.
DR   PANTHER; PTHR33920; PTHR33920; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Plant defense; Reference proteome; Secreted; Signal; Toxin.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..66
FT                   /note="Type-5 thionin"
FT                   /id="PRO_0000034132"
FT   CHAIN           67..131
FT                   /note="Acidic protein"
FT                   /id="PRO_0000034133"
FT   DISULFID        32..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   131 AA;  13748 MW;  101F1544C794EBFB CRC64;
     MGGGQKGLES AIVCLLVLGL VLEQVQVEGV DCGANPFKVA CFNSCLLGPS TVFQCADFCA
     CRLPAGLASV RSSDEPNAIE YCSLGCRSSV CDNMINTADN STEEMKLYVK RCGVACDSFC
     KGDTLLASLD D