ID   THN6_HORVU              Reviewed;         137 AA.
AC   P09618;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 3.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Leaf-specific thionin BTH6;
DE   Contains:
DE     RecName: Full=Leaf-specific thionin BTH6;
DE   Contains:
DE     RecName: Full=Acidic protein;
DE   Flags: Precursor;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Holtorf S., Schuetz C., Apel K., Bohlmann H.;
RT   "Specific and distinct expression patterns of two members of the thionin
RT   multigene family of barley in transgenic tobacco.";
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 29-74.
RC   STRAIN=cv. Carina;
RX   PubMed=16453847; DOI=10.1002/j.1460-2075.1988.tb02980.x;
RA   Bohlmann H., Clausen S., Behnke S., Giese H., Hiller C.,
RA   Reimann-Phillip U., Schrader G., Barkholt V., Apel K.;
RT   "Leaf-specific thionins of barley - a novel class of cell wall proteins
RT   toxic to plant-pathogenic fungi and possibly involved in the defence
RT   mechanism of plants.";
RL   EMBO J. 7:1559-1565(1988).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   EMBL; L36882; AAA91047.1; -; Genomic_DNA.
DR   AlphaFoldDB; P09618; -.
DR   SMR; P09618; -.
DR   ExpressionAtlas; P09618; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Plant defense; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   CHAIN           29..74
FT                   /note="Leaf-specific thionin BTH6"
FT                   /id="PRO_0000034120"
FT   CHAIN           75..137
FT                   /note="Acidic protein"
FT                   /id="PRO_0000034121"
FT   DISULFID        31..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   137 AA;  14717 MW;  559302CCCB34364A CRC64;
     MAPSKSIKSV VICVLILVLV LEQVQVEGKS CCKDTLARNC YNTCRFAGGS RPVCAGACRC
     KIISGPKCPS DYPKLNLLPE SGEPDVTQYC TIGCTNSVCD NMDNVFRGQE MKFDMGLCSN
     ACARFCNDGA VIQSVEA