ID   THNA_PHOLI              Reviewed;          46 AA.
AC   P01540;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   26-FEB-2020, entry version 76.
DE   RecName: Full=Ligatoxin-A;
OS   Phoradendron liga (Argentine mistletoe) (Viscum liga).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Viscaceae; Phoradendron.
OX   NCBI_TaxID=3968;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7136736;
RA   Thunberg E., Samuelsson G.;
RT   "Isolation and properties of ligatoxin A, a toxic protein from the
RT   mistletoe Phoradendron liga.";
RL   Acta Pharm. Suec. 19:285-292(1982).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   PIR; A01803; LOFDAL.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Plant defense; Secreted; Toxin.
FT   CHAIN           1..46
FT                   /note="Ligatoxin-A"
FT                   /id="PRO_0000221486"
FT   DISULFID        3..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   46 AA;  4841 MW;  635EB18CF5A26D5B CRC64;
     KSCCPSTTAR NIYNTCRLTG TSRPTCASLS GCKIISGSTC BSGWBH