ID   THNB_PHOLI              Reviewed;          46 AA.
AC   P59358;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2003, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Ligatoxin-B;
OS   Phoradendron liga (Argentine mistletoe) (Viscum liga).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Viscaceae; Phoradendron.
OX   NCBI_TaxID=3968;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=12049612; DOI=10.1042/bj20020221;
RA   Li S.S., Gullbo J., Lindholm P., Larsson R., Thunberg E., Samuelsson G.,
RA   Bohlin L., Claeson P.;
RT   "Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-
RT   binding domain from the mistletoe Phoradendron liga.";
RL   Biochem. J. 366:405-413(2002).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MISCELLANEOUS: The predicted 3D structure shares similarity with the
CC       HTH DNA-binding motifs, leading to the suggestion that the
CC       intracellular thionins of an infected plant may activate signaling
CC       networks that regulate innate responses, including the hypersensitive
CC       reaction.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P59358; -.
DR   SMR; P59358; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Plant defense; Secreted; Toxin.
FT   CHAIN           1..46
FT                   /note="Ligatoxin-B"
FT                   /id="PRO_0000221487"
FT   DISULFID        3..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   46 AA;  4798 MW;  A041A0C9F5A479D6 CRC64;
     KSCCPSTTAR NIYNTCRLTG ASRSVCASLS GCKIISGSTC DSGWNH