ID   THNB_TRIHA              Reviewed;         580 AA.
AC   A0A0F9XXG3;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2015, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=MFS-type transporter thnB {ECO:0000303|PubMed:33570538};
DE   AltName: Full=Trihazone biosynthesis cluster protein B {ECO:0000303|PubMed:33570538};
GN   Name=thnB {ECO:0000303|PubMed:33570538}; ORFNames=THAR02_03178;
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=5544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776;
RX   PubMed=26067977; DOI=10.1128/genomea.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma harzianum
RT   T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
RN   [2]
RP   FUNCTION.
RX   PubMed=33570538; DOI=10.1039/d0ob02545c;
RA   Zhu Y., Wang J., Mou P., Yan Y., Chen M., Tang Y.;
RT   "Genome mining of cryptic tetronate natural products from a PKS-NRPS
RT   encoding gene cluster in Trichoderma harzianum t-22.";
RL   Org. Biomol. Chem. 19:1985-1990(2021).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that produces
CC       the tetronate natural products trihazones.
CC       {ECO:0000269|PubMed:33570538}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JOKZ01000069; KKP04698.1; -; Genomic_DNA.
DR   EnsemblFungi; KKP04698; KKP04698; THAR02_03178.
DR   OMA; GSAYFMC; -.
DR   OrthoDB; 627633at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..580
FT                   /note="MFS-type transporter thnB"
FT                   /id="PRO_0000455677"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        389..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        529..549
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        285
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   580 AA;  62120 MW;  3120BAD31AC571FF CRC64;
     MSGDYSATRK SENVDTSTTA SQEDSSLAPE QPEKLVGASD VAAVSNNEPT ADEYPHGLRL
     ITLVLAINLA MFLASLDQTI LGTAIPKITD EFHGLSQVSW YGSAYFMCLG GFQSTWGKVY
     KYFPLKISFA IAVFVFELGS LICGVARNSN TFIVGRAIAG IGGAGITSGS TVILAFSAEP
     AKRPTLMSTM GVTYCIAFIL GPLIGGAFSE KVTWRWCFYI NLPIGGLAMA LFFLFFRTPS
     VSTTQDATLK EKLLHMDPVG TVLAMGGIIS FILALQYAGV SHAWNSSVVI GLLVGFVLIM
     VTLAAWEYFQ GDYAMLPYRL FKRRVMWAGG IFQFFFVGCY FLLLFYLPIY FQSIKGVSAI
     HSGVDNLPLV LSACLFIILG GAAVEKTHMA TPYMTAGSAV AAVATGLLYT LDVDTSSGKW
     IGYQVLVGAG LAFPFQNALN ILQAEVDADD MSPATSSLYF FQILGGAFSI SAAQAAFNNR
     LLHSLTINAP GVSPLLVLAT GASDLRSVFS ADELPGVILS YMDGLKAAFA VSVGLVGMAF
     LSSLHMVMID SCETLHTTGD DGAWKGKEVK ELEVERLYVN