ID   THNC_VISAL              Reviewed;          46 AA.
AC   P83554;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Viscotoxin-C1;
OS   Viscum album (European mistletoe).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Viscaceae; Viscum.
OX   NCBI_TaxID=3972 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBUNIT, MASS SPECTROMETRY, AND STRUCTURE BY
RP   NMR.
RC   STRAIN=Subsp. coloratum {ECO:0000269|PubMed:14580196};
RC   TISSUE=Leaf {ECO:0000269|PubMed:14580196};
RX   PubMed=14580196; DOI=10.1021/bi034762t;
RA   Romagnoli S., Fogolari F., Catalano M., Zetta L., Schaller G., Urech K.,
RA   Giannattasio M., Ragona L., Molinari H.;
RT   "NMR solution structure of viscotoxin C1 from Viscum album species
RT   Coloratum ohwi: toward a structure-function analysis of viscotoxins.";
RL   Biochemistry 42:12503-12510(2003).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC       {ECO:0000269|PubMed:14580196}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:14580196}.
CC   -!- MASS SPECTROMETRY: Mass=4945.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:14580196};
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   PDB; 1ORL; NMR; -; A=1-46.
DR   PDB; 3C8P; X-ray; 1.25 A; A/B=1-46.
DR   PDBsum; 1ORL; -.
DR   PDBsum; 3C8P; -.
DR   AlphaFoldDB; P83554; -.
DR   SMR; P83554; -.
DR   EvolutionaryTrace; P83554; -.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Plant defense;
KW   Toxin.
FT   CHAIN           1..46
FT                   /note="Viscotoxin-C1"
FT                   /id="PRO_0000221484"
FT   DISULFID        3..40
FT   DISULFID        4..32
FT   DISULFID        16..26
FT   HELIX           7..19
FT                   /evidence="ECO:0007829|PDB:1ORL"
FT   HELIX           23..30
FT                   /evidence="ECO:0007829|PDB:1ORL"
SQ   SEQUENCE   46 AA;  4947 MW;  61094D4CFE5E9D25 CRC64;
     KSCCPNTTGR NIYNTCRFAG GSRERCAKLS GCKIISASTC PSDYPK