ID   THNS1_MACFA             Reviewed;         743 AA.
AC   Q9BH05;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Threonine synthase-like 1;
DE            Short=TSH1;
GN   Name=THNSL1; ORFNames=QflA-10072;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR   EMBL; AB055251; BAB21875.1; -; mRNA.
DR   AlphaFoldDB; Q9BH05; -.
DR   SMR; Q9BH05; -.
DR   Ensembl; ENSMFAT00000077670; ENSMFAP00000051426; ENSMFAG00000064275.
DR   Ensembl; ENSMFAT00000085006; ENSMFAP00000061334; ENSMFAG00000064275.
DR   GeneTree; ENSGT00940000161144; -.
DR   Proteomes; UP000233100; Chromosome 9.
DR   CDD; cd00464; SK; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.90.1380.10; -; 1.
DR   HAMAP; MF_00109; Shikimate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR031322; Shikimate/glucono_kinase.
DR   InterPro; IPR000623; Shikimate_kinase/TSH1.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF01202; SKI; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR00260; thrC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..743
FT                   /note="Threonine synthase-like 1"
FT                   /id="PRO_0000185647"
FT   MOD_RES         281
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IYQ7"
FT   MOD_RES         351
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   743 AA;  83189 MW;  F4C4773989F72824 CRC64;
     MFHFNRCQHL KKITQKCFSS IHVKTDKHAQ QFLSRTFALA ELRKSWYSTH SLVGDKNIIL
     MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS EKLQDVGNEQ FLEEEGKAVL
     NFSASGSVIS LTGSNPMHDA SMWHLKKNGV IVYLDVPLLD LIHRLKLMKI DRIVGRNSGT
     SMKDLLKFRR QYYKKWYDAR VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPK
     DCEQKVSAKF FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYIE RAQILLERCI
     HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF KDLSLQLMPH
     IFAHCIPPSC NYMILVATSG DTGSAVLNGF SRLNKNDKQR IAVVTFFPEN GVSDFQKAQI
     IGSQRENGWA VGVESDFDFC QTAIKRIFND SDFTGFLTVE YGTILSSANS INWGRLLPQV
     VYHASAYLDL VSQGFISFGS PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNRVL
     TDFIKTGHYD LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNQLESQHHF
     QIEKVLVEKL QQDFVADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA DRVQDKTCPV
     IVSSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA LPPLHEALLE RTKQQEKMEY
     QVCAADMNVL KSHVEKLIQN QFI