THNS1_MOUSE
ID THNS1_MOUSE Reviewed; 747 AA.
AC Q8BH55;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Threonine synthase-like 1;
DE Short=TSH1;
GN Name=Thnsl1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR EMBL; AK029518; BAC26489.1; -; mRNA.
DR EMBL; AK083895; BAC39051.1; -; mRNA.
DR CCDS; CCDS15720.1; -.
DR RefSeq; NP_001001297.1; NM_001001297.2.
DR RefSeq; NP_808256.1; NM_177588.2.
DR RefSeq; XP_006497494.1; XM_006497431.3.
DR RefSeq; XP_006497495.1; XM_006497432.3.
DR RefSeq; XP_006497496.1; XM_006497433.2.
DR AlphaFoldDB; Q8BH55; -.
DR SMR; Q8BH55; -.
DR STRING; 10090.ENSMUSP00000052452; -.
DR iPTMnet; Q8BH55; -.
DR PhosphoSitePlus; Q8BH55; -.
DR MaxQB; Q8BH55; -.
DR PaxDb; Q8BH55; -.
DR PRIDE; Q8BH55; -.
DR ProteomicsDB; 259384; -.
DR Antibodypedia; 25872; 93 antibodies from 20 providers.
DR DNASU; 208967; -.
DR Ensembl; ENSMUST00000054591; ENSMUSP00000052452; ENSMUSG00000048550.
DR GeneID; 208967; -.
DR KEGG; mmu:208967; -.
DR UCSC; uc008inb.1; mouse.
DR CTD; 79896; -.
DR MGI; MGI:2139347; Thnsl1.
DR VEuPathDB; HostDB:ENSMUSG00000048550; -.
DR eggNOG; KOG2616; Eukaryota.
DR GeneTree; ENSGT00940000161144; -.
DR HOGENOM; CLU_015170_3_2_1; -.
DR InParanoid; Q8BH55; -.
DR OMA; DCLAAIH; -.
DR OrthoDB; 1361511at2759; -.
DR PhylomeDB; Q8BH55; -.
DR TreeFam; TF329641; -.
DR BioGRID-ORCS; 208967; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8BH55; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8BH55; protein.
DR Bgee; ENSMUSG00000048550; Expressed in spermatid and 217 other tissues.
DR ExpressionAtlas; Q8BH55; baseline and differential.
DR Genevisible; Q8BH55; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR CDD; cd00464; SK; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.90.1380.10; -; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF53686; SSF53686; 1.
DR TIGRFAMs; TIGR00260; thrC; 1.
PE 1: Evidence at protein level;
KW Pyridoxal phosphate; Reference proteome.
FT CHAIN 1..747
FT /note="Threonine synthase-like 1"
FT /id="PRO_0000185648"
FT MOD_RES 351
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 747 AA; 83100 MW; 4A6524FCE38D8AC2 CRC64;
MLTLTRCHHL KQIAQECLSS LLVKVQSRTQ LLLPRASARA ESGKSWHSTH SLVGDKNIVL
MGPPGSGKTT VGRILGDKLG CCVIDVDSDV LEKAWNMSAS EKLQDVGNER FLEEEGKTVL
NLSASGSVIS LSGSNPMHDA SMWHLKKNGI VVYLDVPLTD IISRLKSMRI DRIVGQNTGA
SLRDSLKHVR LYYKKWYDAR VFCESGASAE EVADKVLDVV KRYQDVDSET FISTRHVCLK
DHDKKFPPKY FSEAVVEGLA SDGGLFVPEK EFPKLSPGEW NNLIGATYIE RAQVLLERCI
HPADIPAAKL GEMIETAYGE NFACSKVAPV RHLSGNQFIL ELFYGPTGSF KDLSLQLMPH
IFAYCIPPGC NYVILVATSG DTGSAVLNGF SHLNKNDKER IAVVTFFPEN GVSDFQKAEI
IGSQRENGWA IGVRSDFDFC QTAIRKIFND SDFTGFLAVE YGTILSSANS INWARLLPQI
VYHASAYLEL VNQRFISFGS PVDVCVPTGN FGNVLAAVYA KMMGIPIRKF ICASNQNHVL
TDFIKTGHYD LRNRKLAQTF SPSIDILKSS NLERHLYLMA NKDGQLMANL YHQLESQLHF
RIEKMLVEKL QQEFVADWCS EGECLAAIST TYNASGYILD PHTAVAKVVA DKMQDKSCPV
LIASTAHYSK FAPAIMQALG IKELNQTSSS QLYLLSSYNA LPPPHEALLE RMKQKEKMDY
QVCVADVDVL KSHAEKLIQN WFVRKSE