ID   THNS1_PONAB             Reviewed;         743 AA.
AC   Q5R5P3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Threonine synthase-like 1;
DE            Short=TSH1;
GN   Name=THNSL1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR   EMBL; CR860814; CAH92923.1; -; mRNA.
DR   RefSeq; NP_001126720.1; NM_001133248.1.
DR   AlphaFoldDB; Q5R5P3; -.
DR   SMR; Q5R5P3; -.
DR   STRING; 9601.ENSPPYP00000003283; -.
DR   GeneID; 100173721; -.
DR   KEGG; pon:100173721; -.
DR   CTD; 79896; -.
DR   eggNOG; KOG2616; Eukaryota.
DR   InParanoid; Q5R5P3; -.
DR   OrthoDB; 1361511at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   CDD; cd00464; SK; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.90.1380.10; -; 1.
DR   HAMAP; MF_00109; Shikimate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR031322; Shikimate/glucono_kinase.
DR   InterPro; IPR000623; Shikimate_kinase/TSH1.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF01202; SKI; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR00260; thrC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..743
FT                   /note="Threonine synthase-like 1"
FT                   /id="PRO_0000185649"
FT   MOD_RES         281
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IYQ7"
FT   MOD_RES         351
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   743 AA;  83004 MW;  6FFF98ECFE0EE84F CRC64;
     MLHFNRCHHL KKITQKCFSS IHVKTDKHAQ QFLSRTFALA ELRKSWYSTH SLVGDKNIIL
     MGPPGAGKTT VGRIIGQKLG CCVIDVDDDI LEKTWNMSVS EKLQDVGNEQ FLEEEGKAVL
     NFSASGSVIS LTGSNPMHDA SMWHLKKNGI IVYLDVPLLD LIHRLKLMKT DRIVGQNSGT
     SVKDLLKFRR QYYKKWYDAR VFCESGASPE EVADKVLNAI KRYQDVDSET FISTRHVWPK
     DGEQKLSAKF FSEAVIEGLA SDGGLFVPAK EFPKLSCGEW KSLVGATYIE RAQILLERCI
     HPADIPAARL GEMIETAYGE NFACSKIAPV RHLSGNQFIL ELFHGPTGSF KDLSLQLMPH
     IFAHCIPPSC NYVILVATSG DTGSAVLNGF SRLNKNDKQR IAVVAFFPEN GVSDFQKAQI
     IGSQRENGWA VGVESDFDFC QTAIKRIFDD SDFTGFLTVE YGTILSSANS INWGRLLPQV
     VYHASAYLDL ISQGFISFGS PVDVCIPTGN FGNILAAVYA KMMGIPIRKF ICASNQNHVL
     TDFIKTGHYD LRERKLAQTF SPSIDILKSS NLERHLHLMA NKDGQLMTEL FNRLESQHHF
     QIEKALVEKL QQDFIADWCS EGECLAAINS TYNTSGYILD PHTAVAKVVA DRVQDKSCPL
     IISSTAHYSK FAPAIMQALK IKEINETSSS QLYLLGSYNA LPPLHEALLE RTKQQEKMEY
     QVCAADVNVL KSHVEKLIQN QFI