ID   THNS2_PONAB             Reviewed;         484 AA.
AC   Q5RFE6;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Threonine synthase-like 2;
DE            Short=TSH2;
DE            EC=4.2.3.-;
GN   Name=THNSL2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a catabolic phospho-lyase on both gamma- and beta-
CC       phosphorylated substrates. Degrades O-phospho-threonine (PThr) to
CC       alpha-ketobutyrate, ammonia and phosphate (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR   EMBL; CR857212; CAH89511.1; -; mRNA.
DR   RefSeq; NP_001127159.1; NM_001133687.1.
DR   AlphaFoldDB; Q5RFE6; -.
DR   SMR; Q5RFE6; -.
DR   STRING; 9601.ENSPPYP00000013604; -.
DR   GeneID; 100174210; -.
DR   KEGG; pon:100174210; -.
DR   CTD; 55258; -.
DR   eggNOG; KOG2616; Eukaryota.
DR   InParanoid; Q5RFE6; -.
DR   OrthoDB; 1361511at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.90.1380.10; -; 1.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF00291; PALP; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR00260; thrC; 1.
PE   2: Evidence at transcript level;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..484
FT                   /note="Threonine synthase-like 2"
FT                   /id="PRO_0000306409"
FT   MOD_RES         113
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   484 AA;  54147 MW;  2D03818632095F2B CRC64;
     MWYVSTRGIA PRVNFEGALF SGYAPDGGLF MPEELPQLDR KTLCQWSTLS YPGLVKELCA
     LFIGSELIPK DELNDLIDRA FSRFRHREVV HLSRLRNGLN VLELWHGVTY AFKDLSLSCT
     AQFLQYFLEK REKHVTVVVG TSGDTGSAAI ESVQGAKNMD IIVLLPKGHC TKIQELQMTT
     VLKENVHVFG VEGNSDELDE PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF
     QCMPSLDTHP LPLVEVVVPT GAAGNLAAGY IAQKIGLPVR LVVAVNGNDI IHRTVQQGDF
     SLSEAVKSTL ASAMDIQVPY NMERVFWLLS GSDSQVTRAL MEQFERTQSV NLPKELHSKL
     SEAVTSVSVS DEAITQTMGR CWDENQYLLC PHSAVAVNYH YQQMDRQQPS TPRCCLAPAS
     AAKFPEAVLA AGLTPETPAE IVALEHKETR CTPMRRGDNW MLMLRDTIED LSRRWRSHAL
     NTSR