ID   THNS2_XENLA             Reviewed;         472 AA.
AC   Q5XH07;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Threonine synthase-like 2;
DE            Short=TSH2;
DE            EC=4.2.3.-;
GN   Name=thnsl2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a catabolic phospho-lyase on both gamma- and beta-
CC       phosphorylated substrates. Degrades O-phospho-threonine (PThr) to
CC       alpha-ketobutyrate, ammonia and phosphate (By similarity).
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the threonine synthase family. {ECO:0000305}.
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DR   EMBL; BC084269; AAH84269.1; -; mRNA.
DR   RefSeq; NP_001088267.1; NM_001094798.1.
DR   AlphaFoldDB; Q5XH07; -.
DR   SMR; Q5XH07; -.
DR   DNASU; 495098; -.
DR   GeneID; 495098; -.
DR   KEGG; xla:495098; -.
DR   CTD; 495098; -.
DR   Xenbase; XB-GENE-5918635; thnsl2.L.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 495098; Expressed in kidney and 19 other tissues.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.90.1380.10; -; 1.
DR   InterPro; IPR001926; PLP-dep.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR036052; Trypto_synt_PLP_dependent.
DR   Pfam; PF00291; PALP; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   SUPFAM; SSF53686; SSF53686; 1.
DR   TIGRFAMs; TIGR00260; thrC; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   2: Evidence at transcript level;
KW   Lyase; Pyridoxal phosphate; Reference proteome.
FT   CHAIN           1..472
FT                   /note="Threonine synthase-like 2"
FT                   /id="PRO_0000306411"
FT   MOD_RES         113
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   472 AA;  53345 MW;  4099F9A95CEC9CAA CRC64;
     MKYTSTRGGL IGVDFEGVLF SGFAPDGGLF MPEDIPKVDK RTLQTWSSYS YIQLVKEICS
     LFISPESIPR ADLEGLIDRA FIRFRHRDIV PITRLKSGLN VMEMWHGVTH AFKDLAMSCV
     GELLDYFLKR KNKHVTILVA TSGDTGSSAI ESVRRRENMD IIVLLPHGRC TKIQELQMTT
     VIEDNVHVFS VDGTSDELDY PIKRLFADSD FVKKHNIMST NSVNWARILV QIAHFFYGYM
     QCAPLTELTP VEIIVPTGGA GNITAGCIAQ AMGLPIHLVA VVNRNDIVHR TVQYGDFSLG
     DTKATLASAM DIQEPYNMER ILWLLAGSEK SHIKEMMKEF QEKKRVKLPE QLHKKIAGAM
     TSCVVTDENI LGTIGRCWEE NHYLLCPHSA VAVYYHYQQM DSNDKSPRCC LAPASAAKFQ
     DVIIKANLTP DIPQEIKDLE KKKTRSHHLT KEDDWEKVLR QTIESISQRK VQ