ID   THNX_HORVU              Reviewed;         137 AA.
AC   Q8H0Q5;
DT   01-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Probable leaf thionin;
DE   Contains:
DE     RecName: Full=Probable leaf thionin;
DE   Contains:
DE     RecName: Full=Acidic protein;
DE   Flags: Precursor;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Manchuria; TISSUE=Leaf;
RA   Kah B., Kogel K.H., Langen G.;
RT   "ORF of a leaf expressed barley thionin.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ508712; CAD48489.1; -; mRNA.
DR   AlphaFoldDB; Q8H0Q5; -.
DR   SMR; Q8H0Q5; -.
DR   ExpressionAtlas; Q8H0Q5; baseline.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Plant defense; Secreted; Signal; Toxin.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..74
FT                   /note="Probable leaf thionin"
FT                   /id="PRO_0000034124"
FT   CHAIN           75..137
FT                   /note="Acidic protein"
FT                   /id="PRO_0000034125"
FT   DISULFID        31..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..60
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..54
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   137 AA;  14615 MW;  752F0489A4FEDC4E CRC64;
     MATNKSIKSV VICVLILGLV LEQVQVEGKS CCKNTTGRNC YNACHFAGGS RPVCATACGC
     KIISGPTCPR DYPKLNLLPE SGEPNATEYC TIGCRTSVCD NMDNVSRGQE MKFDMGLCSN
     ACARFCNDGD VIQSVEA