ID   THN_DENCL               Reviewed;          46 AA.
AC   P01541;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Denclatoxin-B;
OS   Dendrophthora clavata (Columbian mistletoe).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Viscaceae; Dendrophthora.
OX   NCBI_TaxID=3965;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=906843;
RA   Samuelsson G., Pettersson B.;
RT   "Toxic proteins from the mistletoe Dendrophtora clavata. II. The amino acid
RT   sequence of denclatoxin B.";
RL   Acta Pharm. Suec. 14:245-254(1977).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   PIR; A01804; DKDCB.
DR   AlphaFoldDB; P01541; -.
DR   SMR; P01541; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Plant defense; Secreted; Toxin.
FT   CHAIN           1..46
FT                   /note="Denclatoxin-B"
FT                   /id="PRO_0000221485"
FT   DISULFID        3..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        4..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   46 AA;  4821 MW;  C107A82B29ADA608 CRC64;
     KSCCPTTAAR NQYNICRLPG TPRPVCAALS GCKIISGTGC PPGYRH