ID   THN_PHOLT               Reviewed;          46 AA.
AC   P01539;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Phoratoxin;
OS   Phoradendron leucarpum subsp. tomentosum (California mistletoe)
OS   (Phoradendron tomentosum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Santalales; Viscaceae; Phoradendron.
OX   NCBI_TaxID=3969;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=Subsp. macrophyllum;
RX   PubMed=4415051;
RA   Mellstrand S.T., Samuelsson G.;
RT   "Phoratoxin, a toxic protein from the mistletoe Phoradendron tomentosum
RT   subsp. macrophyllum (Loranthaceae). The amino acid sequence.";
RL   Acta Pharm. Suec. 11:347-360(1974).
RN   [2]
RP   PROTEIN SEQUENCE.
RA   Samuelsson G.;
RT   "Mistletoe toxins.";
RL   Syst. Zool. 22:566-569(1973).
RN   [3]
RP   DISULFIDE BONDS.
RX   PubMed=4606908;
RA   Mellstrand S.T., Samuelsson G.;
RT   "Phoratoxin, a toxic protein from the mistletoe Phoradendron tomentosum
RT   subsp. macrophyllum (Loranthaceae). The disulphide bonds.";
RL   Acta Pharm. Suec. 11:367-374(1974).
CC   -!- FUNCTION: Thionins are small plant proteins which are toxic to animal
CC       cells. They seem to exert their toxic effect at the level of the cell
CC       membrane. Their precise function is not known.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the plant thionin (TC 1.C.44) family.
CC       {ECO:0000305}.
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DR   PIR; A01802; VFFD1T.
DR   AlphaFoldDB; P01539; -.
DR   SMR; P01539; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1350.10; -; 1.
DR   InterPro; IPR001010; Thionin.
DR   InterPro; IPR036391; Thionin-like_sf.
DR   PANTHER; PTHR33920; PTHR33920; 1.
DR   Pfam; PF00321; Thionin; 1.
DR   PRINTS; PR00287; THIONIN.
DR   SUPFAM; SSF57429; SSF57429; 1.
DR   PROSITE; PS00271; THIONIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Plant defense; Secreted; Toxin.
FT   CHAIN           1..46
FT                   /note="Phoratoxin"
FT                   /id="PRO_0000221488"
FT   MOD_RES         46
FT                   /note="Blocked carboxyl end (His)"
FT                   /evidence="ECO:0000269|PubMed:4415051"
FT   DISULFID        3..40
FT                   /evidence="ECO:0000305|PubMed:4606908"
FT   DISULFID        4..32
FT                   /evidence="ECO:0000305|PubMed:4606908"
FT   DISULFID        16..26
FT                   /evidence="ECO:0000269|PubMed:4606908"
SQ   SEQUENCE   46 AA;  4881 MW;  A02A08BA4E27D1A9 CRC64;
     KSCCPTTTAR NIYNTCRFGG GSRPVCAKLS GCKIISGTKC DSGWNH