ID   THO5A_ARATH             Reviewed;         452 AA.
AC   F4HRC1;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=THO complex subunit 5A;
DE   AltName: Full=THO complex subunit 5;
DE            Short=AtTHO5;
GN   Name=THO5A; Synonyms=THO5, THOC5B; OrderedLocusNames=At1g45233;
GN   ORFNames=T2P3;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX   PubMed=20634427; DOI=10.1073/pnas.0911341107;
RA   Yelina N.E., Smith L.M., Jones A.M., Patel K., Kelly K.A., Baulcombe D.C.;
RT   "Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene
RT   and endogenous siRNA biosynthesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13948-13953(2010).
CC   -!- FUNCTION: Acts as component of the THO subcomplex of the TREX complex
CC       which is thought to couple mRNA transcription, processing and nuclear
CC       export. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the THO complex, which is composed of THO1, THO2,
CC       THO3, THO5, THO6 and THO7. {ECO:0000269|PubMed:20634427}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the THOC5 family. {ECO:0000305}.
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DR   EMBL; AC084820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002684; AEE32103.1; -; Genomic_DNA.
DR   RefSeq; NP_973979.2; NM_202250.3.
DR   AlphaFoldDB; F4HRC1; -.
DR   SMR; F4HRC1; -.
DR   BioGRID; 26318; 4.
DR   STRING; 3702.AT1G45233.2; -.
DR   PaxDb; F4HRC1; -.
DR   PRIDE; F4HRC1; -.
DR   ProteomicsDB; 246459; -.
DR   EnsemblPlants; AT1G45233.2; AT1G45233.2; AT1G45233.
DR   GeneID; 841093; -.
DR   Gramene; AT1G45233.2; AT1G45233.2; AT1G45233.
DR   KEGG; ath:AT1G45233; -.
DR   Araport; AT1G45233; -.
DR   TAIR; locus:1005716682; AT1G45233.
DR   eggNOG; KOG2216; Eukaryota.
DR   HOGENOM; CLU_546786_0_0_1; -.
DR   OMA; PPHQSAK; -.
DR   OrthoDB; 1048314at2759; -.
DR   PhylomeDB; F4HRC1; -.
DR   PRO; PR:F4HRC1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HRC1; baseline and differential.
DR   GO; GO:0000347; C:THO complex; IDA:UniProtKB.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR019163; THO_Thoc5.
DR   PANTHER; PTHR13375; PTHR13375; 1.
DR   Pfam; PF09766; FmiP_Thoc5; 1.
PE   1: Evidence at protein level;
KW   mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..452
FT                   /note="THO complex subunit 5A"
FT                   /id="PRO_0000425589"
SQ   SEQUENCE   452 AA;  51812 MW;  7EC3A35A16C1E99A CRC64;
     MQSEMAIDTV ATAEKSPLEL LQQTKASVEA IIAKMLSIKQ QGTPKSENRE LLTQMFLNFI
     NLRQANRSIL IEEEKVRTET EIAKSPVDFT TLELHNLMYE KSHYLKANKA SRDFKSRYPN
     IDLISEQDFF SDAPEAIKSQ TLSNDSSHDL MLKRLNFELH QRKELCKLRV RLEQQKKSLL
     ESNAERNKFL SSLPVHLKSL KKASLPVQSQ LSLQNQKKLK YHNLAELLPP PLYVIYSQFM
     ALKEAFEENI DVEVSGSLKD AQTYARQQAE QNSESLRLEV GVDEERQRKR LKKVGSDEGG
     VYQVHPLKVV LHVYDDEITD PKSHELVMLK FEYLLKLNVV CVGIEESEDG LEKNILCNLF
     PDDSGLEPPH QSAKLILGND HVFDKSRTSR PYKWAQHLAG IETLPEMSPF FTDKDIQYSD
     TAKGYASASD HRNVQTVLQR IRSQKKTKLT LV