ID   THO7A_ARATH             Reviewed;         233 AA.
AC   Q8LDS5; A0MFG2; Q9LFD9;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=THO complex subunit 7A;
DE   AltName: Full=THO complex subunit 7;
DE            Short=AtTHO7;
GN   Name=THO7A; Synonyms=THOC7B; OrderedLocusNames=At5g16790;
GN   ORFNames=F5E19.130;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX   PubMed=20634427; DOI=10.1073/pnas.0911341107;
RA   Yelina N.E., Smith L.M., Jones A.M., Patel K., Kelly K.A., Baulcombe D.C.;
RT   "Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene
RT   and endogenous siRNA biosynthesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:13948-13953(2010).
CC   -!- FUNCTION: Acts as component of the THO subcomplex of the TREX complex
CC       which is thought to couple mRNA transcription, processing and nuclear
CC       export. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the THO complex, which is composed of THO1, THO2,
CC       THO3, THO5, THO6 and THO7. {ECO:0000269|PubMed:20634427}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABK28698.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAC01843.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL391147; CAC01843.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED92338.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69742.1; -; Genomic_DNA.
DR   EMBL; DQ446956; ABE66161.1; -; mRNA.
DR   EMBL; DQ653288; ABK28698.1; ALT_SEQ; mRNA.
DR   EMBL; AY085831; AAM63046.1; -; mRNA.
DR   PIR; T51511; T51511.
DR   RefSeq; NP_001331398.1; NM_001343466.1.
DR   RefSeq; NP_568339.1; NM_121685.5.
DR   AlphaFoldDB; Q8LDS5; -.
DR   SMR; Q8LDS5; -.
DR   BioGRID; 16818; 95.
DR   STRING; 3702.AT5G16790.1; -.
DR   PaxDb; Q8LDS5; -.
DR   PRIDE; Q8LDS5; -.
DR   ProteomicsDB; 246462; -.
DR   EnsemblPlants; AT5G16790.1; AT5G16790.1; AT5G16790.
DR   EnsemblPlants; AT5G16790.2; AT5G16790.2; AT5G16790.
DR   GeneID; 831542; -.
DR   Gramene; AT5G16790.1; AT5G16790.1; AT5G16790.
DR   Gramene; AT5G16790.2; AT5G16790.2; AT5G16790.
DR   KEGG; ath:AT5G16790; -.
DR   Araport; AT5G16790; -.
DR   TAIR; locus:2149020; AT5G16790.
DR   eggNOG; KOG3215; Eukaryota.
DR   HOGENOM; CLU_076737_0_0_1; -.
DR   InParanoid; Q8LDS5; -.
DR   OMA; WANSKND; -.
DR   OrthoDB; 1273269at2759; -.
DR   PhylomeDB; Q8LDS5; -.
DR   PRO; PR:Q8LDS5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q8LDS5; baseline and differential.
DR   Genevisible; Q8LDS5; AT.
DR   GO; GO:0000347; C:THO complex; IDA:UniProtKB.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR008501; THOC7/Mft1.
DR   Pfam; PF05615; THOC7; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW   Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..233
FT                   /note="THO complex subunit 7A"
FT                   /id="PRO_0000425591"
FT   COILED          101..221
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   233 AA;  26985 MW;  2C78CFC4BA713EFC CRC64;
     MSVRARRIVS GRSETVAANY AFDPLHDDKI IRNRLLTRTT TTRGEPPLKK LQKKFTSFVI
     ELDKEEDNYS ECGRLAKAFL QELSAFEIPL LKSQVVVAAN LREKENFNEL KDETNRQIMQ
     AQADIEDLKK QLEESKIERQ QKEECEAIRK LISAQPPRSE TQKVIHELKK EIAELEAENT
     ASWRLLELRK KQFALLLHVV DELQETMEDE QKSMVEEMQR NITADGAEAM SID