THO7B_ARATH
ID THO7B_ARATH Reviewed; 236 AA.
AC Q9M8T6;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=THO complex subunit 7B;
DE AltName: Full=THO complex subunit 7;
DE Short=AtTHO7;
GN Name=THO7B; Synonyms=THOC7A; OrderedLocusNames=At3g02950;
GN ORFNames=F13E7.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBUNIT.
RX PubMed=20634427; DOI=10.1073/pnas.0911341107;
RA Yelina N.E., Smith L.M., Jones A.M., Patel K., Kelly K.A., Baulcombe D.C.;
RT "Putative Arabidopsis THO/TREX mRNA export complex is involved in transgene
RT and endogenous siRNA biosynthesis.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:13948-13953(2010).
CC -!- FUNCTION: Acts as component of the THO subcomplex of the TREX complex
CC which is thought to couple mRNA transcription, processing and nuclear
CC export. {ECO:0000250}.
CC -!- SUBUNIT: Component of the THO complex, which is composed of THO1, THO2,
CC THO3, THO5, THO6 and THO7. {ECO:0000269|PubMed:20634427}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC018363; AAF26964.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73884.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65748.1; -; Genomic_DNA.
DR EMBL; AF424596; AAL11590.1; -; mRNA.
DR EMBL; BT014879; AAT41862.1; -; mRNA.
DR RefSeq; NP_001327695.1; NM_001337451.1.
DR RefSeq; NP_566189.1; NM_111165.4.
DR AlphaFoldDB; Q9M8T6; -.
DR SMR; Q9M8T6; -.
DR BioGRID; 6507; 95.
DR STRING; 3702.AT3G02950.1; -.
DR iPTMnet; Q9M8T6; -.
DR PaxDb; Q9M8T6; -.
DR PRIDE; Q9M8T6; -.
DR ProteomicsDB; 246463; -.
DR EnsemblPlants; AT3G02950.1; AT3G02950.1; AT3G02950.
DR EnsemblPlants; AT3G02950.2; AT3G02950.2; AT3G02950.
DR GeneID; 821174; -.
DR Gramene; AT3G02950.1; AT3G02950.1; AT3G02950.
DR Gramene; AT3G02950.2; AT3G02950.2; AT3G02950.
DR KEGG; ath:AT3G02950; -.
DR Araport; AT3G02950; -.
DR TAIR; locus:2075377; AT3G02950.
DR eggNOG; KOG3215; Eukaryota.
DR HOGENOM; CLU_076737_0_0_1; -.
DR InParanoid; Q9M8T6; -.
DR OMA; SHYAFGP; -.
DR OrthoDB; 1273269at2759; -.
DR PhylomeDB; Q9M8T6; -.
DR PRO; PR:Q9M8T6; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M8T6; baseline and differential.
DR Genevisible; Q9M8T6; AT.
DR GO; GO:0000347; C:THO complex; IDA:UniProtKB.
DR GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR008501; THOC7/Mft1.
DR Pfam; PF05615; THOC7; 1.
PE 1: Evidence at protein level;
KW Coiled coil; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW Reference proteome; RNA-binding; Transport.
FT CHAIN 1..236
FT /note="THO complex subunit 7B"
FT /id="PRO_0000425592"
FT COILED 99..228
FT /evidence="ECO:0000255"
SQ SEQUENCE 236 AA; 27461 MW; AF7941920478521E CRC64;
MSVKARRISG RLETVVTKVN YAFDPVDDDK IIRNRLLTRT TTTRGEPPLK KLQKKFTSFV
LEVDKEEENY NDCGRLAKAF LQELSTFEIP LLKSQAVVEA NLREKESFNE VKDETERQIM
QAKAEIEDLK KQLEESKIDR QHKEECETIR KLISAQPPRS ETEKVIYELN KEIAELEAES
TASWRLLELR KKQFALLMHV VDELQNTMED EQKSLVDEIR SASEDQRNIT DAMSVD
