ID   THOC5_CHICK             Reviewed;         698 AA.
AC   Q5ZJK1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=THO complex subunit 5 homolog;
GN   Name=THOC5; ORFNames=RCJMB04_17i18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Acts as component of the THO subcomplex of the TREX complex
CC       which is thought to couple mRNA transcription, processing and nuclear
CC       export, and which specifically associates with spliced mRNA and not
CC       with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a
CC       transcription-independent mechanism, binds to mRNA upstream of the
CC       exon-junction complex (EJC) and is recruited in a splicing- and cap-
CC       dependent manner to a region near the 5' end of the mRNA where it
CC       functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: May be involved in cell differentiation. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the THO complex, which is composed of THOC1,
CC       THOC2, THOC3, THOC5, THOC6 and THOC7; together with at least
CC       ALYREF/THOC4, DDX39B, SARNP/CIP29 and CHTOP, THO forms the
CC       transcription/export (TREX) complex which seems to have a dynamic
CC       structure involving ATP-dependent remodeling. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13769}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q13769}. Note=Shuttles between nucleus and
CC       cytoplasm. {ECO:0000250|UniProtKB:Q13769}.
CC   -!- SIMILARITY: Belongs to the THOC5 family. {ECO:0000305}.
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DR   EMBL; AJ720433; CAG32092.1; -; mRNA.
DR   RefSeq; NP_001006195.1; NM_001006195.1.
DR   AlphaFoldDB; Q5ZJK1; -.
DR   SMR; Q5ZJK1; -.
DR   STRING; 9031.ENSGALP00000037250; -.
DR   PaxDb; Q5ZJK1; -.
DR   GeneID; 417019; -.
DR   KEGG; gga:417019; -.
DR   CTD; 8563; -.
DR   VEuPathDB; HostDB:geneid_417019; -.
DR   eggNOG; KOG2216; Eukaryota.
DR   HOGENOM; CLU_023759_1_0_1; -.
DR   InParanoid; Q5ZJK1; -.
DR   OrthoDB; 1048314at2759; -.
DR   PhylomeDB; Q5ZJK1; -.
DR   PRO; PR:Q5ZJK1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:2000002; P:negative regulation of DNA damage checkpoint; ISS:UniProtKB.
DR   GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR019163; THO_Thoc5.
DR   PANTHER; PTHR13375; PTHR13375; 2.
DR   Pfam; PF09766; FmiP_Thoc5; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; mRNA processing; mRNA splicing; mRNA transport;
KW   Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..698
FT                   /note="THO complex subunit 5 homolog"
FT                   /id="PRO_0000310557"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..327
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           6..9
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   698 AA;  80581 MW;  8879AF0226B2FC3B CRC64;
     MSSDSKKRKP KVIRTDGGPQ EGKRGKADGE QDARYYSEEC EVDLRDPIKD YELYKETCQE
     LQRLMAEIQE LKSRGVKDNA SEIDERRVQS CVHFMTLKKL NRLAHIRLKK GRDQTHEAKQ
     KVDAYHLQLQ NLLYEVMHLQ KEITKCLEFK SKHEEIELVS LEEFYSEAPT EISRPDITLT
     EPHQQTLARL DWELEQRKRL AERYKECQTI KEKILKEIEV KKEYLSSLQP RLNSIMQASL
     PVQEYLFMPF DQAHKQYETA RHLPPPLYVL FVQASAYGQA CDKKLVVAIE GSVEEAKALY
     KPPEDSQDDE SDSDMEEEQT TKRRRPTLGV QLDDKRKEML KRHPLSVTVD LKCKDENVLH
     LTFYYLMNLN IMTVLHLTFY YLMNLNIMTV KTKVTTAAEL TTAISAGDLL SPDSLLSCLY
     PGDHGKKTPN PANQFQFDKV GILTLSDYVT ELGHPYVWVQ KLGGLHFPKD QPQHTVTADN
     SLSASHMEMT MKLLRTRLQS RLALHKQFAS LEHGVVPVSS ECQHLFPTKI VSRLVKWTAI
     PFEDYTELPY TKDVVEAGLA EDTHLYYMAL IERGTAKLQA AVVLNPGYSA LPPIFSLCLN
     WKGERTGSND DNIRAMESEV NVCYKELWGP KPGYQLLTNQ LQRLCMVLDV YLETEPHDTT
     VEGPKEFPQE KMCLRLVRGP MRLKPFKFNY PQGFFSHR