THOC6_DROME
ID THOC6_DROME Reviewed; 350 AA.
AC Q9VTV1; Q705B9;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=THO complex subunit 6;
GN Name=thoc6; ORFNames=CG5632;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND IDENTIFICATION IN THE THO
RP COMPLEX.
RX PubMed=15133499; DOI=10.1038/nsmb759;
RA Rehwinkel J., Herold A., Gari K., Koecher T., Rode M., Ciccarelli F.L.,
RA Wilm M., Izaurralde E.;
RT "Genome-wide analysis of mRNAs regulated by the THO complex in
RT Drosophila.";
RL Nat. Struct. Mol. Biol. 11:558-566(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: The THO complex is required for cell proliferation and for
CC proper export of heat-shock mRNAs under heat stress.
CC {ECO:0000269|PubMed:15133499}.
CC -!- SUBUNIT: Part of the THO complex containing HPR1, THOC2, THOC5, THOC6
CC and THOC7. {ECO:0000269|PubMed:15133499}.
CC -!- SIMILARITY: Belongs to the WD repeat THOC6 family. {ECO:0000305}.
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DR EMBL; AJ620303; CAF04330.1; -; mRNA.
DR EMBL; AE014296; AAF49944.1; -; Genomic_DNA.
DR EMBL; AY061521; AAL29069.1; -; mRNA.
DR RefSeq; NP_001261750.1; NM_001274821.1.
DR RefSeq; NP_001303370.1; NM_001316441.1.
DR RefSeq; NP_648557.1; NM_140300.4.
DR AlphaFoldDB; Q9VTV1; -.
DR SMR; Q9VTV1; -.
DR BioGRID; 64748; 7.
DR STRING; 7227.FBpp0075751; -.
DR PaxDb; Q9VTV1; -.
DR DNASU; 39394; -.
DR EnsemblMetazoa; FBtr0076019; FBpp0075751; FBgn0036263.
DR EnsemblMetazoa; FBtr0333384; FBpp0305576; FBgn0036263.
DR EnsemblMetazoa; FBtr0346911; FBpp0312410; FBgn0036263.
DR GeneID; 39394; -.
DR KEGG; dme:Dmel_CG5632; -.
DR UCSC; CG5632-RA; d. melanogaster.
DR CTD; 79228; -.
DR FlyBase; FBgn0036263; thoc6.
DR VEuPathDB; VectorBase:FBgn0036263; -.
DR eggNOG; KOG0649; Eukaryota.
DR HOGENOM; CLU_060667_0_0_1; -.
DR InParanoid; Q9VTV1; -.
DR OMA; QHTSMLE; -.
DR OrthoDB; 760323at2759; -.
DR PhylomeDB; Q9VTV1; -.
DR Reactome; R-DME-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-DME-72187; mRNA 3'-end processing.
DR Reactome; R-DME-73856; RNA Polymerase II Transcription Termination.
DR BioGRID-ORCS; 39394; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39394; -.
DR PRO; PR:Q9VTV1; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036263; Expressed in ovary and 18 other tissues.
DR ExpressionAtlas; Q9VTV1; baseline and differential.
DR Genevisible; Q9VTV1; DM.
DR GO; GO:0000347; C:THO complex; IDA:UniProtKB.
DR GO; GO:0000346; C:transcription export complex; ISS:FlyBase.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0031990; P:mRNA export from nucleus in response to heat stress; IC:FlyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR042626; THOC6.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44411; PTHR44411; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Reference proteome; WD repeat.
FT CHAIN 1..350
FT /note="THO complex subunit 6"
FT /id="PRO_0000310752"
FT REPEAT 151..191
FT /note="WD"
FT REGION 328..350
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..342
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 36..37
FT /note="VL -> IP (in Ref. 1; CAF04330)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="I -> T (in Ref. 1; CAF04330)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 350 AA; 39221 MW; 387C577C73302FBA CRC64;
MKQKDLKRAY NNVLAQAISG SKQYLFAGNL FGDIFVLRIK ELDKGSEEPP GKLKIFPQGS
DVDINYLAFH RDFLIVGAVG LIYGLEWNEE EESLATKRSW EVKIPMQVDA VEVPDVNSMW
LDSENSILFA GCGDGVIYQV SLEDGRIQRE YRGHTDYVHS VVGNANGQIF SGAEDGTVRV
WSTKQQQHTS MLEPYKNPNL LRPDWGKWIG AVAVNEDWLL CGGGPKASIF HLRSMESTCV
FSFPGRVHLC DFVDDCVLIG GEHNHVQSYT LNGVLQANIP VEHTACYSAV WQTSPIKFIS
IAGFSNKLHI LKDFRFLDSK IEMYGNVEGE ENDPEEEDEL IEKPLTVEAA
