ID   THOC7_DANRE             Reviewed;         202 AA.
AC   Q6DGZ3;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=THO complex subunit 7 homolog;
GN   Name=thoc7; ORFNames=zgc:92711;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient export of polyadenylated RNA. Acts as
CC       component of the THO subcomplex of the TREX complex which is thought to
CC       couple mRNA transcription, processing and nuclear export, and which
CC       specifically associates with spliced mRNA and not with unspliced pre-
CC       mRNA. TREX is recruited to spliced mRNAs by a transcription-independent
CC       mechanism, binds to mRNA upstream of the exon-junction complex (EJC)
CC       and is recruited in a splicing- and cap-dependent manner to a region
CC       near the 5' end of the mRNA where it functions in mRNA export to the
CC       cytoplasm via the TAP/NFX1 pathway. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBUNIT: Component of the THO subcomplex of the transcription/export
CC       (TREX) complex which seems to have a dynamic structure involving ATP-
CC       dependent remodeling. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
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DR   EMBL; BC076191; AAH76191.1; -; mRNA.
DR   RefSeq; NP_001003429.1; NM_001003429.2.
DR   AlphaFoldDB; Q6DGZ3; -.
DR   SMR; Q6DGZ3; -.
DR   STRING; 7955.ENSDARP00000022217; -.
DR   PaxDb; Q6DGZ3; -.
DR   Ensembl; ENSDART00000005639; ENSDARP00000022217; ENSDARG00000015394.
DR   GeneID; 445035; -.
DR   KEGG; dre:445035; -.
DR   CTD; 80145; -.
DR   ZFIN; ZDB-GENE-040801-17; thoc7.
DR   eggNOG; KOG3215; Eukaryota.
DR   GeneTree; ENSGT00390000002873; -.
DR   HOGENOM; CLU_087727_0_0_1; -.
DR   InParanoid; Q6DGZ3; -.
DR   OMA; WANSKND; -.
DR   OrthoDB; 1394258at2759; -.
DR   PhylomeDB; Q6DGZ3; -.
DR   TreeFam; TF319308; -.
DR   Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-DRE-72187; mRNA 3'-end processing.
DR   Reactome; R-DRE-73856; RNA Polymerase II Transcription Termination.
DR   PRO; PR:Q6DGZ3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 11.
DR   Bgee; ENSDARG00000015394; Expressed in early embryo and 29 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR008501; THOC7/Mft1.
DR   Pfam; PF05615; THOC7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; mRNA transport;
KW   Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..202
FT                   /note="THO complex subunit 7 homolog"
FT                   /id="PRO_0000310756"
FT   REGION          181..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          86..167
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  23643 MW;  6E8A4828D6BD6BF1 CRC64;
     MGSITDDEVI RKRLLIDGDG AGDDRRINVL MKSFTKWCHS SFSPEEGMSQ YQRMMMSLAQ
     CEFSMGKTLL VYNMNLKEME NYEGIYTDIE KSIASAHEKI AECKKEIQRA KRIRKNRQEY
     DALARVIKQH PDRHETLKQL EALDKDLQQL SHIKENVEDK LELRKKQFHV LLTTIQELQQ
     TLENDEKMES DDTQDSPMEN GD