ID   THOC7_NEMVE             Reviewed;         205 AA.
AC   A7RX34;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=THO complex subunit 7 homolog;
GN   Name=thoc7; ORFNames=v1g163685;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: May act as component of the THO subcomplex of the TREX
CC       complex which is thought to couple mRNA transcription, processing and
CC       nuclear export, and which specifically associates with spliced mRNA and
CC       not with unspliced pre-mRNA. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBUNIT: Component of the THO subcomplex of the transcription/export
CC       (TREX) complex which seems to have a dynamic structure involving ATP-
CC       dependent remodeling. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
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DR   EMBL; DS469549; EDO43898.1; -; Genomic_DNA.
DR   RefSeq; XP_001635961.1; XM_001635911.1.
DR   AlphaFoldDB; A7RX34; -.
DR   SMR; A7RX34; -.
DR   STRING; 45351.EDO43898; -.
DR   EnsemblMetazoa; EDO43898; EDO43898; NEMVEDRAFT_v1g163685.
DR   GeneID; 5515860; -.
DR   KEGG; nve:5515860; -.
DR   eggNOG; KOG3215; Eukaryota.
DR   HOGENOM; CLU_087727_0_0_1; -.
DR   InParanoid; A7RX34; -.
DR   OMA; WANSKND; -.
DR   OrthoDB; 1394258at2759; -.
DR   PhylomeDB; A7RX34; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR   InterPro; IPR008501; THOC7/Mft1.
DR   Pfam; PF05615; THOC7; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..205
FT                   /note="THO complex subunit 7 homolog"
FT                   /id="PRO_0000349102"
FT   REGION          181..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          68..158
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23738 MW;  2B17E72AB5744985 CRC64;
     MADDEVIRKR LLIDGEGVGD DRRITTLMKT FVKWCNSTDD DNDASYQKLL AQLAQCEFAM
     GKTEMVHAMN ERETENYEKA YKEVEQSITH AYEEIATCKT NLQEAKRIRR NKQEYDALAK
     EITKHPERQE TTRQISELEK DLNSLTETKE SLVSKLELRK KQFYLLINTI HELQRMIDDE
     KTDEGTALSP QQSITSPGKV ALMDT