ID   THOC7_XENLA             Reviewed;         201 AA.
AC   Q7SZ78;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=THO complex subunit 7 homolog;
GN   Name=thoc7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient export of polyadenylated RNA. Acts as
CC       component of the THO subcomplex of the TREX complex which is thought to
CC       couple mRNA transcription, processing and nuclear export, and which
CC       specifically associates with spliced mRNA and not with unspliced pre-
CC       mRNA. TREX is recruited to spliced mRNAs by a transcription-independent
CC       mechanism, binds to mRNA upstream of the exon-junction complex (EJC)
CC       and is recruited in a splicing- and cap-dependent manner to a region
CC       near the 5' end of the mRNA where it functions in mRNA export to the
CC       cytoplasm via the TAP/NFX1 pathway. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBUNIT: Component of the THO subcomplex of the transcription/export
CC       (TREX) complex which seems to have a dynamic structure involving ATP-
CC       dependent remodeling. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
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DR   EMBL; BC053810; AAH53810.1; -; mRNA.
DR   RefSeq; NP_001080651.1; NM_001087182.2.
DR   AlphaFoldDB; Q7SZ78; -.
DR   SMR; Q7SZ78; -.
DR   IntAct; Q7SZ78; 1.
DR   PRIDE; Q7SZ78; -.
DR   DNASU; 380343; -.
DR   GeneID; 380343; -.
DR   KEGG; xla:380343; -.
DR   CTD; 380343; -.
DR   Xenbase; XB-GENE-956295; thoc7.S.
DR   OMA; WANSKND; -.
DR   OrthoDB; 1394258at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 380343; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR008501; THOC7/Mft1.
DR   Pfam; PF05615; THOC7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; mRNA transport;
KW   Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..201
FT                   /note="THO complex subunit 7 homolog"
FT                   /id="PRO_0000310757"
FT   REGION          182..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          75..194
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   201 AA;  23371 MW;  984434ADD790FE62 CRC64;
     MGAVTDDEVI RKRLLIDGDG AGDDRRINLL VKSFVKWCNS GSQEEGYSQY QRMLSSLSQC
     EYSMGKTLLV HDMNLREMEN YEKIYVDIES SIAAAHEKIA ECKKQILQAK RIRKNRQEYD
     ALAKVIEQHP DRHETLKQLE ALDKELKQLS HTKENAEDKL ELRRKQFHVL LSTIHELQQT
     LENDDKLAEE SQESPMETQN P