ID   THOC7_XENTR             Reviewed;         199 AA.
AC   Q6P643;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=THO complex subunit 7 homolog;
GN   Name=thoc7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient export of polyadenylated RNA. Acts as
CC       component of the THO subcomplex of the TREX complex which is thought to
CC       couple mRNA transcription, processing and nuclear export, and which
CC       specifically associates with spliced mRNA and not with unspliced pre-
CC       mRNA. TREX is recruited to spliced mRNAs by a transcription-independent
CC       mechanism, binds to mRNA upstream of the exon-junction complex (EJC)
CC       and is recruited in a splicing- and cap-dependent manner to a region
CC       near the 5' end of the mRNA where it functions in mRNA export to the
CC       cytoplasm via the TAP/NFX1 pathway. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBUNIT: Component of the THO subcomplex of the transcription/export
CC       (TREX) complex which seems to have a dynamic structure involving ATP-
CC       dependent remodeling. {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus
CC       {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle
CC       {ECO:0000250|UniProtKB:Q6I9Y2}.
CC   -!- SIMILARITY: Belongs to the THOC7 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC062491; AAH62491.1; -; mRNA.
DR   RefSeq; NP_989103.1; NM_203772.1.
DR   AlphaFoldDB; Q6P643; -.
DR   SMR; Q6P643; -.
DR   STRING; 8364.ENSXETP00000056903; -.
DR   DNASU; 394707; -.
DR   Ensembl; ENSXETT00000056903; ENSXETP00000056903; ENSXETG00000006539.
DR   GeneID; 394707; -.
DR   KEGG; xtr:394707; -.
DR   CTD; 80145; -.
DR   Xenbase; XB-GENE-956290; thoc7.
DR   eggNOG; KOG3215; Eukaryota.
DR   InParanoid; Q6P643; -.
DR   OrthoDB; 1394258at2759; -.
DR   Reactome; R-XTR-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-XTR-72187; mRNA 3'-end processing.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000006539; Expressed in embryo and 14 other tissues.
DR   ExpressionAtlas; Q6P643; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000445; C:THO complex part of transcription export complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR008501; THOC7/Mft1.
DR   Pfam; PF05615; THOC7; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; mRNA processing; mRNA splicing; mRNA transport;
KW   Nucleus; Reference proteome; RNA-binding; Transport.
FT   CHAIN           1..199
FT                   /note="THO complex subunit 7 homolog"
FT                   /id="PRO_0000310758"
FT   COILED          73..192
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  23146 MW;  9318AF3DFFD5591B CRC64;
     MGAVTDDEVI RKRLLIDGDG AGDDRRINLL VKSFLKWCNS GSQEEGQYQR MLSSLSQCEF
     SMGKTLLVHD MNLREMENYE KIYVDIESSI AAAHEKIAEC KKQILQAKRI RKNRQEYDAL
     AKVIQQHPDR HETLKQLEAL DKELKQLSHT KENVEDKLEL RRKQFHVLLS TIHELQQTLE
     NDDKLAEESQ ESPMETQNP