ID   THP1A_XENLA             Reviewed;         225 AA.
AC   Q5U560;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=THAP domain-containing protein 1 A;
GN   Name=thap1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA-binding transcription regulator that regulates
CC       endothelial cell proliferation and G1/S cell-cycle progression.
CC       Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence
CC       and acts by modulating expression of pRB-E2F cell-cycle target genes
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the THAP1 family. {ECO:0000305}.
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DR   EMBL; BC084824; AAH84824.1; -; mRNA.
DR   RefSeq; NP_001088492.1; NM_001095023.2.
DR   AlphaFoldDB; Q5U560; -.
DR   SMR; Q5U560; -.
DR   DNASU; 495360; -.
DR   GeneID; 495360; -.
DR   KEGG; xla:495360; -.
DR   CTD; 495360; -.
DR   Xenbase; XB-GENE-1008764; thap1.L.
DR   OMA; LMPPLHT; -.
DR   OrthoDB; 1382095at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 495360; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   Gene3D; 6.20.210.20; -; 1.
DR   InterPro; IPR026516; THAP1.
DR   InterPro; IPR006612; THAP_Znf.
DR   InterPro; IPR038441; THAP_Znf_sf.
DR   PANTHER; PTHR46600; PTHR46600; 1.
DR   Pfam; PF05485; THAP; 1.
DR   SMART; SM00692; DM3; 1.
DR   SMART; SM00980; THAP; 1.
DR   PROSITE; PS50950; ZF_THAP; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Coiled coil; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..225
FT                   /note="THAP domain-containing protein 1 A"
FT                   /id="PRO_0000367845"
FT   ZN_FING         5..57
FT                   /note="THAP-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00309"
FT   COILED          139..194
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   225 AA;  26198 MW;  4AC5A8230257CD84 CRC64;
     MVQSCSAYGC KNRYDKDKPI SFHKFPLKRP LLCKKWEAAV RRAEFKPTKY SSICSDHFSA
     DCFKRECNNK LLKDNAVPTI FAHMEIKKKS GKAVKKEQLP AEPEPVPAVP EIDPAIGLLL
     PPLYTPSHIA VICDHNYTVE DTVHQRRRIQ QLEEQVDKLR KKLKIANQKC RRQERSLEKL
     EREVSEYREA KGSGYVIFPG NYYEVLNENE YKELTPEITY KEIIL