ID   THPS_BOVIN              Reviewed;          49 AA.
AC   P01251;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Splenin;
DE   AltName: Full=Thymopoietin III;
GN   Name=SP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7306506; DOI=10.1021/bi00524a044;
RA   Audhya T., Schlesinger D.H., Goldstein G.;
RT   "Complete amino acid sequences of bovine thymopoietins I, II, and III:
RT   closely homologous polypeptides.";
RL   Biochemistry 20:6195-6200(1981).
CC   -!- FUNCTION: Hormone of the spleen with pleiotropic actions on
CC       prothymocytes, mature T-cells, the nicotinic acetylcholine receptor,
CC       and pituitary corticotrophs.
CC   -!- SIMILARITY: Belongs to the thymopoietin family. {ECO:0000305}.
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DR   PIR; B01518; TOBO3.
DR   AlphaFoldDB; P01251; -.
DR   SMR; P01251; -.
DR   STRING; 9913.ENSBTAP00000048213; -.
DR   eggNOG; ENOG502QWCI; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.720.40; -; 1.
DR   InterPro; IPR013146; LEM-like_dom.
DR   InterPro; IPR011015; LEM/LEM-like_dom_sf.
DR   Pfam; PF08198; Thymopoietin; 1.
DR   SMART; SM01261; Thymopoietin; 1.
DR   SUPFAM; SSF63451; SSF63451; 1.
DR   PROSITE; PS50955; LEM_LIKE; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome.
FT   CHAIN           1..49
FT                   /note="Splenin"
FT                   /id="PRO_0000206148"
FT   DOMAIN          4..47
FT                   /note="LEM-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00314"
FT   REGION          32..36
FT                   /note="Essential for biological activity"
SQ   SEQUENCE   49 AA;  5639 MW;  7D349FA7C6780AF8 CRC64;
     PEFLEDPSVL TKEKLKSELV ANNVTLPAGE QRKEVYVELY LQHLTALKR